Literature DB >> 7843333

Powerful hepatoprotective and hepatotoxic plant oligostilbenes, isolated from the Oriental medicinal plant Vitis coignetiae (Vitaceae).

Y Oshima1, K Namao, A Kamijou, S Matsuoka, M Nakano, K Terao, Y Ohizumi.   

Abstract

The methanol extract of the Oriental medicinal plant Vitis coignetiae (Vitaceae) showed hepatoprotective activity in the in vitro assay method using primary cultured rat hepatocytes. Activity-guided fractionation of the extract afforded epsilon-viniferin as an active principle. The protective effect of epsilon-viniferin against mice carbon tetrachloride-induced hepatic injury in mice was shown by serum enzyme assay as well as by pathological examination. In addition to epsilon-viniferin, plant oligostilbenes, ampelopsins A, C, F and the mixture of vitisin A and cis-vitisin A were also present in the extract. Among them, ampelopsin C and the mixture of vitisin A and cis-vitisin A were found to be powerful hepatotoxins.

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Year:  1995        PMID： 7843333     DOI： 10.1007/bf01964921

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Transaminase activity in human blood.

Authors:  A KARMEN; F WROBLEWSKI; J S LADUE
Journal:  J Clin Invest       Date:  1955-01       Impact factor: 14.808

2.  Antihepatotoxic actions of Formosan plant drugs.

Authors:  L L Yang; K Y Yen; Y Kiso; H Hikino
Journal:  J Ethnopharmacol       Date:  1987 Jan-Feb       Impact factor: 4.360

Review 3.  Carbon tetrachloride hepatotoxicity.

Authors:  R O Recknagel
Journal:  Pharmacol Rev       Date:  1967-06       Impact factor: 25.468

4.  A new class of phytoalexins from grapevines.

Authors:  P Langcake; R J Pryce
Journal:  Experientia       Date:  1977-02-15

5.  Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes.

Authors:  Y Kiso; M Tohkin; H Hikino
Journal:  Planta Med       Date:  1983-12       Impact factor: 3.352

6.  Necrogenic action of carbon tetrachloride in the rat: a speculative mechanism based on activation.

Authors:  T F Slater
Journal:  Nature       Date:  1966-01-01       Impact factor: 49.962

7.  Assay method for antihepatotoxic activity using galactosamine-induced cytotoxicity in primary-cultured hepatocytes.

Authors:  Y Kiso; M Tohkin; H Hikino
Journal:  J Nat Prod       Date:  1983 Nov-Dec       Impact factor: 4.050
  7 in total
  7 in total

Review 1.  In the shadow of resveratrol: biological activities of epsilon-viniferin.

Authors:  Pauline Beaumont; Arnaud Courtois; Claude Atgié; Tristan Richard; Stéphanie Krisa
Journal:  J Physiol Biochem       Date:  2022-03-21       Impact factor: 4.158

2.  In Vitro Glucuronidation and Sulfation of ε-Viniferin, a Resveratrol Dimer, in Humans and Rats.

Authors:  Arnaud Courtois; Michael Jourdes; Adeline Dupin; Caroline Lapèze; Elodie Renouf; Benoît Biais; Pierre-Louis Teissedre; Jean-Michel Mérillon; Tristan Richard; Stéphanie Krisa
Journal:  Molecules       Date:  2017-05-03       Impact factor: 4.411

Review 3.  In silico evaluation of Vitis amurensis Rupr. Polyphenol compounds for their inhibition potency against COVID-19 main enzymes Mpro and RdRp.

Authors:  Imen Souid; Atef Korchef; Safouan Souid
Journal:  Saudi Pharm J       Date:  2022-02-25       Impact factor: 4.562

Review 4.  The Chemistry and Biological Activities of Natural Products from Northern African Plant Families: From Taccaceae to Zygophyllaceae.

Authors:  Fidele Ntie-Kang; Leonel E Njume; Yvette I Malange; Stefan Günther; Wolfgang Sippl; Joseph N Yong
Journal:  Nat Prod Bioprospect       Date:  2016-03-01

5.  Inhibition of Adipocyte Differentiation by Anthocyanins Isolated from the Fruit of Vitis coignetiae Pulliat is Associated with the Activation of AMPK Signaling Pathway.

Authors:  Min Ho Han; Hong Jae Kim; Jin-Woo Jeong; Cheol Park; Byung Woo Kim; Yung Hyun Choi
Journal:  Toxicol Res       Date:  2018-01-15

6.  Acuminatol and other antioxidative resveratrol oligomers from the stem bark of Shorea acuminata.

Authors:  Norhayati Muhammad; Laily B Din; Idin Sahidin; Siti Farah Hashim; Nazlina Ibrahim; Zuriati Zakaria; Wan A Yaacob
Journal:  Molecules       Date:  2012-07-30       Impact factor: 4.411

Review 7.  Herbal bioactivation: the good, the bad and the ugly.

Authors:  Shufeng Zhou; Hwee-Ling Koh; Yihuai Gao; Zhi-yuan Gong; Edmund Jon Deoon Lee
Journal:  Life Sci       Date:  2004-01-09       Impact factor: 5.037
  7 in total

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