Literature DB >> 7843132

DNA single-strand breaks and cytotoxicity induced by chromate(VI), cadmium(II), and mercury(II) in hydrogen peroxide-resistant cell lines.

K Tsuzuki1, M Sugiyama, N Haramaki.   

Abstract

The induction of cytotoxicity and DNA single-strand breaks by chromium(VI), cadmium(II), and mercury(II) were compared in H2O2-resistant Chinese hamster ovary (CHO(R)) cells and parental (CHO(P)) cells. Using a colony-forming assay, CHO(R) cells were found to be significantly more resistant than CHO(P) cells to the cytotoxicity caused by CdCl2 and HgCl2, but not to that caused by Na2CrO4. However, the DNA single-strand breaks produced by each of these metals were significantly lower in the CHO(R) cells. With respect to chromium reduction, the level of chromium(V) in CHO(R) cells was decreased. The role of intracellular active oxygen in the heavy metal-induced DNA damage and cytotoxicity is discussed.

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Year:  1994        PMID： 7843132      PMCID： PMC1567393          DOI： 10.1289/ehp.94102s3341

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  14 in total

1.  Effect of vitamin E on survival, glutathione reductase and formation of chromium (V) in Chinese hamster V-79 cells treated with sodium chromate (VI).

Authors:  M Sugiyama; A Ando; R Ogura
Journal:  Carcinogenesis       Date:  1989-04       Impact factor: 4.944

2.  Generation of PM2 DNA breaks in the course of reduction of chromium(VI) by glutathione.

Authors:  A Kortenkamp; Z Ozolins; D Beyersmann; P O'Brien
Journal:  Mutat Res       Date:  1989-02       Impact factor: 2.433

Review 3.  Genotoxicity of chromium compounds. A review.

Authors:  S De Flora; M Bagnasco; D Serra; P Zanacchi
Journal:  Mutat Res       Date:  1990-03       Impact factor: 2.433

4.  The DNA cleavage induced by a chromium(V) complex and by chromate and glutathione is mediated by activated oxygen species.

Authors:  A Kortenkamp; G Oetken; D Beyersmann
Journal:  Mutat Res       Date:  1990-10       Impact factor: 2.433

5.  Evidence for a Fenton-type mechanism for the generation of .OH radicals in the reduction of Cr(VI) in cellular media.

Authors:  X L Shi; N S Dalal
Journal:  Arch Biochem Biophys       Date:  1990-08-15       Impact factor: 4.013

6.  DNA single-strand breaks and cytotoxicity induced by sodium chromate(VI) in hydrogen peroxide-resistant cell lines.

Authors:  M Sugiyama; K Tsuzuki; N Haramaki
Journal:  Mutat Res       Date:  1993-04       Impact factor: 2.433

7.  Effect of ascorbic acid on DNA damage, cytotoxicity, glutathione reductase, and formation of paramagnetic chromium in Chinese hamster V-79 cells treated with sodium chromate(VI).

Authors:  M Sugiyama; K Tsuzuki; R Ogura
Journal:  J Biol Chem       Date:  1991-02-25       Impact factor: 5.157

8.  Mechanism of HgCl2 cytotoxicity in cultured mammalian cells.

Authors:  O Cantoni; N T Christie; A Swann; D B Drath; M Costa
Journal:  Mol Pharmacol       Date:  1984-09       Impact factor: 4.436

9.  Participation of active oxygen species in the induction of DNA single-strand scissions by cadmium chloride in cultured Chinese hamster cells.

Authors:  T Ochi; T Ishiguro; M Ohsawa
Journal:  Mutat Res       Date:  1983-11       Impact factor: 2.433

10.  Reaction of chromium (VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage.

Authors:  J Aiyar; H J Berkovits; R A Floyd; K E Wetterhahn
Journal:  Chem Res Toxicol       Date:  1990 Nov-Dec       Impact factor: 3.739
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  8 in total

1.  Assessment of Pb, Cd and Hg soil contamination and its potential to cause cytotoxic and genotoxic effects in human cell lines (CaCo-2 and HaCaT).

Authors:  Maida Sljivic Husejnovic; Martina Bergant; Sasa Jankovic; Suzana Zizek; Aida Smajlovic; Adaleta Softic; Omer Music; Biljana Antonijevic
Journal:  Environ Geochem Health       Date:  2018-01-23       Impact factor: 4.609

2.  Comparative Study of Cytotoxicity, DNA Damage and Oxidative Stress Induced by Heavy Metals Cd(II), Hg(II) and Cr(III) in Yeast.

Authors:  Jingwen Wang; Zhijia Fang; Jian Gao; Lijun Sun; Yaling Wang; Ying Liu; Ravi Gooneratne
Journal:  Curr Microbiol       Date:  2021-03-26       Impact factor: 2.188

3.  In vivo reduction of chromium (VI) and its related free radical generation.

Authors:  K J Liu; X Shi
Journal:  Mol Cell Biochem       Date:  2001-06       Impact factor: 3.396

4.  Potential effects of environmental contaminants on P450 aromatase activity and DNA damage in swallows from the Rio Grande and Somerville, Texas.

Authors:  M A Sitzlar; M A Mora; J G W Fleming; F W Bazer; J W Bickham; C W Matson
Journal:  Ecotoxicology       Date:  2008-08-01       Impact factor: 2.823

5.  Genotoxic potency of mercuric chloride in gill cells of marine gastropod Planaxis sulcatus using comet assay.

Authors:  J Bhagat; B S Ingole
Journal:  Environ Sci Pollut Res Int       Date:  2015-03-12       Impact factor: 4.223

Review 6.  Heavy metal toxicity and the environment.

Authors:  Paul B Tchounwou; Clement G Yedjou; Anita K Patlolla; Dwayne J Sutton
Journal:  Exp Suppl       Date:  2012

7.  Cadmium Chloride Induces DNA Damage and Apoptosis of Human Liver Carcinoma Cells via Oxidative Stress.

Authors:  Anthony Skipper; Jennifer N Sims; Clement G Yedjou; Paul B Tchounwou
Journal:  Int J Environ Res Public Health       Date:  2016-01-02       Impact factor: 3.390

Review 8.  New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases.

Authors:  Joy Mitra; Erika N Guerrero; Pavana M Hegde; Haibo Wang; Istvan Boldogh; Kosagi Sharaf Rao; Sankar Mitra; Muralidhar L Hegde
Journal:  Biomolecules       Date:  2014-07-17
  8 in total

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