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Literature DB >> 7843111

Effects of zinc and cadmium on apoptotic DNA fragmentation in isolated bovine liver nuclei.

Abstract

Isolated nuclei from mammalian cells contain a calcium-dependent endonuclease. The produced DNA fragmentation is a necessary step in the sequence of events resulting in apoptosis (programmed cell death). We report here that zinc and cadmium inhibit the calcium-dependent endonuclease. The essential metal ion zinc may counterbalance the calcium-mediated apoptosis. In contrast to zinc, cadmium alone stimulates the endonuclease by replacing calcium. Thus cadmium exerts a dual effect: micromolar concentrations inhibit the apoptotic endonuclease in the presence but activate the enzyme in the absence of calcium.

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Year: 1994 PMID： 7843111 PMCID： PMC1567406 DOI： 10.1289/ehp.94102s3269

Source DB: PubMed Journal: Environ Health Perspect ISSN： 0091-6765 Impact factor: 9.031

20 in total

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Authors: D J Thomas; T C Caffrey
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