Literature DB >> 7843097

Metal replacement in "zinc finger" and its effect on DNA binding.

P F Predki1, B Sarkar.   

Abstract

Metal replacement studies were used to investigate the metal requirement of a bacterially expressed polypeptide encoding the zinc finger DNA binding domain of the estrogen receptor. Apopolypeptide was generated by dialysis of native polypeptide against low-pH buffer under reducing conditions. Specific DNA binding can be restored by refolding the apopolypeptide in the presence of ionic zinc, cadmium, or cobalt. However, refolding in the presence of copper or nickel fails to regenerate DNA binding activity. While cobalt-reconstituted polypeptide has a reduced affinity for its AGGTCA-binding site compared to zinc- or cadmium-polypeptide, it has the surprising property of increased cooperative DNA binding. Our work indicates that metal substitution results in a range of effects upon DNA binding in vitro. The potential biological significance of metal substitution in vivo is discussed.

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Year:  1994        PMID： 7843097      PMCID： PMC1567423          DOI： 10.1289/ehp.94102s3195

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  17 in total

1.  Solution structure of the glucocorticoid receptor DNA-binding domain.

Authors:  T Härd; E Kellenbach; R Boelens; B A Maler; K Dahlman; L P Freedman; J Carlstedt-Duke; K R Yamamoto; J A Gustafsson; R Kaptein
Journal:  Science       Date:  1990-07-13       Impact factor: 47.728

Review 2.  Finger-loops, oncogenes, and metals. Claude Passmore Brown memorial lecture.

Authors:  F W Sunderman; A M Barber
Journal:  Ann Clin Lab Sci       Date:  1988 Jul-Aug       Impact factor: 1.256

3.  An estrogen-responsive element derived from the 5' flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells.

Authors:  L Klein-Hitpass; M Schorpp; U Wagner; G U Ryffel
Journal:  Cell       Date:  1986-09-26       Impact factor: 41.582

4.  Solution structure of the DNA-binding domain of the oestrogen receptor.

Authors:  J W Schwabe; D Neuhaus; D Rhodes
Journal:  Nature       Date:  1990-11-29       Impact factor: 49.962

5.  The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain.

Authors:  L P Freedman; B F Luisi; Z R Korszun; R Basavappa; P B Sigler; K R Yamamoto
Journal:  Nature       Date:  1988-08-11       Impact factor: 49.962

6.  Effect of zinc and/or pyridoxine deficiency upon oestrogen retention and oestrogen receptor distribution in the rat uterus.

Authors:  G E Bunce; M Vessal
Journal:  J Steroid Biochem       Date:  1987-03       Impact factor: 4.292

7.  Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide.

Authors:  O I Aruoma; B Halliwell; E Gajewski; M Dizdaroglu
Journal:  Biochem J       Date:  1991-02-01       Impact factor: 3.857

8.  DNA- and protein-scission activities of ascorbate in the presence of copper ion and a copper-peptide complex.

Authors:  S H Chiou
Journal:  J Biochem       Date:  1983-10       Impact factor: 3.387

9.  Multiple DNA-binding estrogen receptor forms resolved by interaction with immobilized metal ions. Identification of a metal-binding domain.

Authors:  T W Hutchens; C M Li; Y Sato; T T Yip
Journal:  J Biol Chem       Date:  1989-10-15       Impact factor: 5.157

Review 10.  The steroid and thyroid hormone receptor superfamily.

Authors:  R M Evans
Journal:  Science       Date:  1988-05-13       Impact factor: 47.728
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  15 in total

1.  History of biological metal utilization inferred through phylogenomic analysis of protein structures.

Authors:  Christopher L Dupont; Andrew Butcher; Ruben E Valas; Philip E Bourne; Gustavo Caetano-Anollés
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-24       Impact factor: 11.205

2.  Metallothionein isoform 3 overexpression is associated with breast cancers having a poor prognosis.

Authors:  M A Sens; S Somji; S H Garrett; C L Beall; D A Sens
Journal:  Am J Pathol       Date:  2001-07       Impact factor: 4.307

3.  Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α-DNA interactions.

Authors:  Brian J Deegan; Anna M Bona; Vikas Bhat; David C Mikles; Caleb B McDonald; Kenneth L Seldeen; Amjad Farooq
Journal:  J Mol Recognit       Date:  2011 Nov-Dec       Impact factor: 2.137

Review 4.  The role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not?

Authors:  Natalie B Aquino; Mary B Sevigny; Jackielyn Sabangan; Maggie C Louie
Journal:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev       Date:  2012       Impact factor: 3.781

5.  Specific labeling of zinc finger proteins using noncanonical amino acids and copper-free click chemistry.

Authors:  Younghoon Kim; Sung Hoon Kim; Dean Ferracane; John A Katzenellenbogen; Charles M Schroeder
Journal:  Bioconjug Chem       Date:  2012-08-30       Impact factor: 4.774

Review 6.  Structural and Functional Diversity of Estrogen Receptor Ligands.

Authors:  Amjad Farooq
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

7.  Elevated copper remodels hepatic RNA processing machinery in the mouse model of Wilson's disease.

Authors:  Jason L Burkhead; Martina Ralle; Phillip Wilmarth; Larry David; Svetlana Lutsenko
Journal:  J Mol Biol       Date:  2010-12-10       Impact factor: 5.469

8.  A systems approach implicates nuclear receptor targeting in the Atp7b(-/-) mouse model of Wilson's disease.

Authors:  Phillip A Wilmarth; Kristopher K Short; Oliver Fiehn; Svetlana Lutsenko; Larry L David; Jason L Burkhead
Journal:  Metallomics       Date:  2012-05-08       Impact factor: 4.526

9.  Non-linear effects in the formation of DNA damage in medaka fish fibroblast cells caused by combined action of cadmium and ionizing radiation.

Authors:  Dmytro Grygoryev; Oleksandr Moskalenko; John D Zimbrick
Journal:  Dose Response       Date:  2007-11-23       Impact factor: 2.658

10.  First comparative transcriptomic analysis of wild adult male and female Lutzomyia longipalpis, vector of visceral leishmaniasis.

Authors:  Christina B McCarthy; María Soledad Santini; Paulo F P Pimenta; Luis A Diambra
Journal:  PLoS One       Date:  2013-03-12       Impact factor: 3.240
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