OBJECTIVE: To determine the role of genetic predisposition in the etiology of head and neck squamous cell carcinoma. DESIGN: Retrospective study. SETTING: The outpatient clinics of the departments of otorhinolaryngology and maxillofacial surgery. PATIENTS: First-degree relatives of patients with new head and neck cancer, with first-degree relatives of the patients' spouses as controls. MAIN OUTCOME MEASURE: Occurrence of cancer of the respiratory and upper digestive tract in relatives of patients with head and neck cancer and controls. RESULTS: First-degree relatives (n = 617) of 105 patients with head and neck cancer had 31 cases of cancer of the respiratory and upper digestive tract vs 10 cases in the control group (n = 618) (relative risk, 3.5; P = .0002). This higher rate of cancer was even larger in siblings (16 vs 2, relative risk, 14.6; P = .0001). CONCLUSIONS: Genetic predisposition is an important risk factor for squamous cell carcinoma of the head and neck.
OBJECTIVE: To determine the role of genetic predisposition in the etiology of head and neck squamous cell carcinoma. DESIGN: Retrospective study. SETTING: The outpatient clinics of the departments of otorhinolaryngology and maxillofacial surgery. PATIENTS: First-degree relatives of patients with new head and neck cancer, with first-degree relatives of the patients' spouses as controls. MAIN OUTCOME MEASURE: Occurrence of cancer of the respiratory and upper digestive tract in relatives of patients with head and neck cancer and controls. RESULTS: First-degree relatives (n = 617) of 105 patients with head and neck cancer had 31 cases of cancer of the respiratory and upper digestive tract vs 10 cases in the control group (n = 618) (relative risk, 3.5; P = .0002). This higher rate of cancer was even larger in siblings (16 vs 2, relative risk, 14.6; P = .0001). CONCLUSIONS: Genetic predisposition is an important risk factor for squamous cell carcinoma of the head and neck.
Authors: Eva Negri; Paolo Boffetta; Julien Berthiller; Xavier Castellsague; Maria Paula Curado; Luigino Dal Maso; Alexander W Daudt; Eleonora Fabianova; Leticia Fernandez; Victor Wünsch-Filho; Silvia Franceschi; Richard B Hayes; Rolando Herrero; Sergio Koifman; Philip Lazarus; Juan J Lence; Fabio Levi; Dana Mates; Elena Matos; Ana Menezes; Joshua Muscat; Jose Eluf-Neto; Andrew F Olshan; Peter Rudnai; Oxana Shangina; Erich M Sturgis; Neonilia Szeszenia-Dabrowska; Renato Talamini; Qingyi Wei; Deborah M Winn; David Zaridze; Jolanta Lissowska; Zuo-Feng Zhang; Gilles Ferro; Paul Brennan; Carlo La Vecchia; Mia Hashibe Journal: Int J Cancer Date: 2009-01-15 Impact factor: 7.396
Authors: Rui-Pionheiro Albuquerque; Jose López-López; Enrique Jané-Salas; Jorge Rosa-Santos; Carlos Ibrahim Journal: Med Oral Patol Oral Cir Bucal Date: 2012-07-01