| Literature DB >> 7838000 |
F M Corrigan1, S MacDonald, A Brown, K Armstrong, E M Armstrong.
Abstract
Following observation of fatigue syndromes in people who have been occupationally exposed to pesticides and insecticides which exert their toxicity through the GABAa receptor, we have formulated the hypothesis that fatigue syndromes in general may be secondary to altered sensitivity of the GABAa receptor. We discuss the possible involvement of organochlorine compounds which are widespread in the environment. Organophosphate compounds may have similar toxic effects through damaged cholinergic input to the dentate gyrus of the hippocampus where cholinergic and GABAergic transmission are closely linked.Entities:
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Year: 1994 PMID： 7838000 DOI： 10.1016/0306-9877(94)90065-5
Source DB: PubMed Journal: Med Hypotheses ISSN： 0306-9877 Impact factor: 1.538