Literature DB >> 7837226

Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors.

B E Maryanoff1, W Ho, D F McComsey, A B Reitz, P P Grous, S O Nortey, R P Shank, B Dubinsky, R J Taylor, J F Gardocki.   

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Year:  1995        PMID： 7837226     DOI： 10.1021/jm00001a005

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  6 in total

1.  Metabolism of the new nonbenzodiazepine anxiolytic agent, RWJ-51204, in mouse, rat, dog, monkey and human hepatic S9 fractions, and in rats, dogs and humans.

Authors:  W N Wu; L A McKown; A B Reitz
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Oct-Dec       Impact factor: 2.441

2.  Human hepatic metabolism of the anxiolytic agent, RWJ-51521--API-MS/MS identification of metabolites.

Authors:  W N Wu; L A McKown; A B Reitz
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2004 Oct-Dec       Impact factor: 2.441

3.  Antioxidative and antiproliferative activities of novel pyrido[1,2-a]benzimidazoles.

Authors:  Martina Tireli; Kristina Starčević; Tamara Martinović; Sandra Kraljević Pavelić; Grace Karminski-Zamola; Marijana Hranjec
Journal:  Mol Divers       Date:  2016-09-27       Impact factor: 2.943

4.  Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.

Authors:  Wu-Nan Wu; Linda A McKown; Allen B Reitz
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2006 Oct-Dec       Impact factor: 2.441

5.  Synthesis, characterization, and biological evaluation of benzimidazole derivatives as potential anxiolytics.

Authors:  Dt Nannapaneni; Atyam Vsss Gupta; Mi Reddy; Raidu Ch Sarva
Journal:  J Young Pharm       Date:  2010-07

6.  De Novo Design of Potent, Insecticidal Synthetic Mimics of the Spinosyn Macrolide Natural Products.

Authors:  Gary D Crouse; David A Demeter; Geno Samaritoni; Casandra L McLeod; Thomas C Sparks
Journal:  Sci Rep       Date:  2018-03-20       Impact factor: 4.379
  6 in total

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