Subclinical cervicovaginal human papillomavirus infections associated with cervical condylomata and dysplasia. Treatment outcomes.

Seventy-seven women with subclinical cervicovaginal human papillomavirus (HPV) changes associated with cervical condylomata and/or mild or moderate cervical dysplasia were studied. All patients were treated with the CO2 laser for cervical lesions (condylomata and/or dysplasia) and, subsequently, based on their contraceptive history, were treated either with 5-fluorouracil (5-FU) cream or trichloroacetic acid (TCA). Those who did not wish to be treated were followed similarly to those who were treated. Overall there was no significant difference between those who had no treatment and those who received TCA or 5-FU. Those treated with 5-FU did more poorly as compared to the other two treatment groups with cervical condylomata and dysplasia at the three- and six-month follow-up (P < .05), and the results for TCA were not different from those in women who were observed and underwent no treatment. It appears that the treatment modalities used in this study did not have any beneficial effect on associated subclinical HPV infections.