| Literature DB >> 7836967 |
T Kimura1, T Hisano, H Yoshida, K Ueda, T Miyakawa.
Abstract
We evaluated the proportion of classic plaques among all of the senile plaques in four Alzheimer brains (frontal, temporal, occipital and hippocampal areas) by the usual method of two-dimensional analysis using a single methenamine silver-stained section and three-dimensional analysis using a set of serial sections. Three-dimensional analysis showed the number and percentage of classic plaques to be 2-5 times greater than those revealed by two-dimensional analysis. In the hippocampal area of one case, no classic plaques were found by two-dimensional analysis but three-dimensional analysis showed that some classic plaques were present. From these findings, it is suggested that three-dimensional analysis using serial sections is indispensable for subclassifying senile plaques.Entities:
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Year: 1994 PMID： 7836967 DOI： 10.1007/bf00920628
Source DB: PubMed Journal: J Neurol ISSN： 0340-5354 Impact factor: 4.849