| Literature DB >> 7836853 |
R A Gatti1, E Lange, G Rotman, X Chen, N Uhrhammer, T Liang, S Chiplunkar, L Yang, N Udar, S Dandekar, S Sheikhavandi, Z Wang, H M Yang, J Polikow, M Elashoff, M Teletar, O Sanal, L Chessa, C McConville, M Taylor, Y Shiloh, O Porras, A L Borresen, R D Wegner, C Curry, S Gerken, K Lange, P Concannon.
Abstract
The genotyping data given localize the major A-T gene to an approximately 850 kb region. They also localize the group A A-T gene (ATA) to a region that contains the approximately 850 kb region. They are compatible with linking A-TFresno to 11q22-23. NBS-V2 does not link to this region. Four non-linking families contain only single affecteds, suggesting that these may be spontaneous mutations rather than evidence for an A-T gene outside the 11q22-23 region. Finally, two other non-linking families contain recombinant haplotypes that are compatible with a second A-T gene at 11q22-23, slightly distal to the approximately 850 kb region. However, convincing evidence for a second gene is still lacking.Entities:
Mesh：
Year: 1994 PMID： 7836853
Source DB: PubMed Journal: Int J Radiat Biol ISSN： 0955-3002 Impact factor: 2.694