| Literature DB >> 7836667 |
M Adner1, I Jansen, L Edvinsson.
Abstract
Endothelin-1 (ET-1), an endothelium-derived vasoconstrictor peptide, produced strong contractions in human cerebral, meningeal and temporal arteries. The isopeptides ET-2 and ET-3 also showed potent constrictor activity; however, ET-3 was less potent. The selective ETA receptor antagonist FR 139317 mediated a shift to the right of the concentration-response curve of ET-1. These results suggest that the powerful constriction elicited by the endothelin-isopeptides in cerebral, meningeal and temporal arteries is mediated through ETA receptors.Entities:
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Year: 1994 PMID： 7836667 DOI： 10.1016/0165-1838(94)90098-1
Source DB: PubMed Journal: J Auton Nerv Syst ISSN： 0165-1838