Literature DB >> 7835905

cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12.

C K Garcia1, X Li, J Luna, U Francke.   

Abstract

Lactate and pyruvate are transported across cell membranes by monocarboxylate transporters (MCTs). Here, we use the recently cloned cDNA for hamster MCT1 to isolate cDNA and genomic clones for human MCT1. Comparison of the human and hamster amino acid sequences revealed that the proteins are 86% identical. The gene for human MCT1 (gene symbol, SLC16A1) was localized to human chromosome bands 1p13.2-p12 by PCR analysis of panels of human x rodent cell hybrid lines and by fluorescence chromosomal in situ hybridization.

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Year:  1994        PMID： 7835905     DOI： 10.1006/geno.1994.1532

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  25 in total

Review 1.  Role of plasma membrane transporters in muscle metabolism.

Authors:  A Zorzano; C Fandos; M Palacín
Journal:  Biochem J       Date:  2000-08-01       Impact factor: 3.857

Review 2.  Oligodendroglia: metabolic supporters of axons.

Authors:  Brett M Morrison; Youngjin Lee; Jeffrey D Rothstein
Journal:  Trends Cell Biol       Date:  2013-08-27       Impact factor: 20.808

3.  Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1).

Authors:  R C Poole; C E Sansom; A P Halestrap
Journal:  Biochem J       Date:  1996-12-15       Impact factor: 3.857

4.  Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes.

Authors:  Mahmoud L Soliman; Colin K Combs; Thad A Rosenberger
Journal:  J Neuroimmune Pharmacol       Date:  2012-12-12       Impact factor: 4.147

5.  Neuroprotective role of monocarboxylate transport during glucose deprivation in slice cultures of rat hippocampus.

Authors:  H L Cater; C D Benham; L E Sundstrom
Journal:  J Physiol       Date:  2001-03-01       Impact factor: 5.182

6.  Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation.

Authors:  V N Jackson; N T Price; L Carpenter; A P Halestrap
Journal:  Biochem J       Date:  1997-06-01       Impact factor: 3.857

7.  Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1.

Authors:  Mark A Cuff; Daniel W Lambert; Soraya P Shirazi-Beechey
Journal:  J Physiol       Date:  2002-03-01       Impact factor: 5.182

Review 8.  Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter.

Authors:  C Juel; A P Halestrap
Journal:  J Physiol       Date:  1999-06-15       Impact factor: 5.182

Review 9.  The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

Authors:  Andrew P Halestrap; David Meredith
Journal:  Pflugers Arch       Date:  2003-05-09       Impact factor: 3.657

10.  Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate.

Authors:  A Ritzhaupt; I S Wood; A Ellis; K B Hosie; S P Shirazi-Beechey
Journal:  J Physiol       Date:  1998-12-15       Impact factor: 5.182
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