Literature DB >> 7831391

Immunotoxins in the therapy of cancer: from bench to clinic.

V Ghetie1, E Vitetta.   

Abstract

This review presents only those contributions that have progressed from the bench to the clinic using murine monoclonal antibodies coupled chemically to toxins, their subunits or ribosome-inactivating proteins. The rationale and progress in the development, characterization, preclinical testing and clinical trials are discussed.

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Year:  1994        PMID： 7831391     DOI： 10.1016/0163-7258(94)90025-6

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  7 in total

Review 1.  Building better monoclonal antibody-based therapeutics.

Authors:  George J Weiner
Journal:  Nat Rev Cancer       Date:  2015-06       Impact factor: 60.716

Review 2.  The transferrin receptor and the targeted delivery of therapeutic agents against cancer.

Authors:  Tracy R Daniels; Ezequiel Bernabeu; José A Rodríguez; Shabnum Patel; Maggie Kozman; Diego A Chiappetta; Eggehard Holler; Julia Y Ljubimova; Gustavo Helguera; Manuel L Penichet
Journal:  Biochim Biophys Acta       Date:  2011-08-05

3.  Hepatoxicity of ricin, saporin or a saporin immunotoxin: xanthine oxidase activity in rat liver and blood serum.

Authors:  M G Battelli; L Buonamici; L Polito; A Bolognesi; F Stirpe
Journal:  Virchows Arch       Date:  1996-02       Impact factor: 4.064

Review 4.  Chemical construction of immunotoxins.

Authors:  V Ghetie; E S Vitetta
Journal:  Mol Biotechnol       Date:  2001-07       Impact factor: 2.860

5.  Design, characterization and anti-tumour cytotoxicity of a panel of recombinant, mammalian ribonuclease-based immunotoxins.

Authors:  M P Deonarain; A A Epenetos
Journal:  Br J Cancer       Date:  1998-02       Impact factor: 7.640

Review 6.  Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects.

Authors:  Artem V Domashevskiy; Dixie J Goss
Journal:  Toxins (Basel)       Date:  2015-01-28       Impact factor: 4.546

Review 7.  Antibody Conjugates-Recent Advances and Future Innovations.

Authors:  Donmienne Leung; Jacqueline M Wurst; Tao Liu; Ruben M Martinez; Amita Datta-Mannan; Yiqing Feng
Journal:  Antibodies (Basel)       Date:  2020-01-08
  7 in total

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