Literature DB >> 7830943

omega-Conotoxin GVIA binds to and blocks rat neuromuscular junction.

G Rossoni1, F Berti, L La Maestra, F Clementi.   

Abstract

The effect of omega-conotoxin GVIA, a specific blocker of N-type calcium channels, on the synaptic transmission at the mammalian neuromuscular junction is controversial. We have found that 125I-omega-conotoxin binds to rat tibialis muscle end-plate; that omega-conotoxin blocks the neuromuscular transmission both in vivo, in the sciatic nerve-tibialis anterior muscle, and in vitro in the isolated phrenic nerve-diaphragm preparation; and does not affect muscle nicotinic receptors. We conclude that in rat neuromuscular junctions N-type calcium channels are important for neurotransmitter secretion.

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Year:  1994        PMID： 7830943     DOI： 10.1016/0304-3940(94)90078-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

Review 1.  Metabolism and trafficking of N-type voltage-operated calcium channels in neurosecretory cells.

Authors:  E Sher; P Rosa; M Francolini; A Codignola; E Morlacchi; E Taverna; F Giovannini; A Brioschi; F Clementi; M W McEnery; M Passafaro
Journal:  J Bioenerg Biomembr       Date:  1998-08       Impact factor: 2.945

2.  Lambert-Eaton sera reduce low-voltage and high-voltage activated Ca2+ currents in murine dorsal root ganglion neurons.

Authors:  K D García; M Mynlieff; D B Sanders; K G Beam; J P Walrond
Journal:  Proc Natl Acad Sci U S A       Date:  1996-08-20       Impact factor: 11.205

3.  Localization of Ca2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals.

Authors:  R E Westenbroek; L Hoskins; W A Catterall
Journal:  J Neurosci       Date:  1998-08-15       Impact factor: 6.167

4.  Reduction of calcium currents by Lambert-Eaton syndrome sera: motoneurons are preferentially affected, and L-type currents are spared.

Authors:  K D García; K G Beam
Journal:  J Neurosci       Date:  1996-08-15       Impact factor: 6.167

5.  Differential localization of voltage-dependent calcium channel alpha1 subunits at the human and rat neuromuscular junction.

Authors:  N C Day; S J Wood; P G Ince; S G Volsen; W Smith; C R Slater; P J Shaw
Journal:  J Neurosci       Date:  1997-08-15       Impact factor: 6.167

6.  Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission.

Authors:  C E Wright; J A Angus
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

7.  Calcium channel subtypes contributing to acetylcholine release from normal, 4-aminopyridine-treated and myasthenic syndrome auto-antibodies-affected neuromuscular junctions.

Authors:  F Giovannini; E Sher; R Webster; J Boot; B Lang
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

8.  Calcium channels coupled to neurotransmitter release at neonatal rat neuromuscular junctions.

Authors:  M D Rosato Siri; O D Uchitel
Journal:  J Physiol       Date:  1999-01-15       Impact factor: 5.182

9.  Tissue- and cell-specific expression of a splice variant in the II-III cytoplasmic loop of Cacna1b.

Authors:  Alexandra Bunda; Brianna LaCarubba; Marie Akiki; Arturo Andrade
Journal:  FEBS Open Bio       Date:  2019-07-28       Impact factor: 2.792
  9 in total

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