| Literature DB >> 7829766 |
A H Young1, A L Sharpley, G M Campling, R A Hockney, P J Cowen.
Abstract
The effects of hydrocortisone administration (20 mg, orally, twice daily) on the sensitivity of brain 5-HT1A receptors in healthy volunteers were studied using a buspirone challenge paradigm. The effects of hydrocortisone administration on sleep architecture were also studied. Hydrocortisone treatment significantly attenuated the hypothermic and cortisol responses to buspirone; however, the prolactin and growth hormone responses were unchanged. Hydrocortisone also decreased the amount of rapid eye movement sleep (REM). The ability of hydrocortisone to attenuate 5-HT1A receptor mediated hypothermia and decrease REM sleep is shared by certain antidepressant treatments and may be related to the effects of corticosteroids on mood.Entities:
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Year: 1994 PMID： 7829766 DOI： 10.1016/0165-0327(94)90072-8
Source DB: PubMed Journal: J Affect Disord ISSN： 0165-0327 Impact factor: 4.839