Literature DB >> 782960

Efficacy of a live oral cholera vaccine in human volunteers.

W E Woodward, R H Gilman, R B Hornick, J P Libonati, R A Cash.   

Abstract

A live attenuated oral cholera vaccine has been given to volunteers with complete safety. The vaccine strain appeared to multiply significantly in intestinal contents and to result in appreciable vibriocidal antibody response. Subsequent challenge with virulent Inaba vibrios demonstrated substantial protection from clinical illness and from vibrio shedding. The possibility of reversion to toxin production is discussed.

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Year:  1976        PMID： 782960

Source DB:  PubMed          Journal:  Dev Biol Stand        ISSN： 0301-5149


  7 in total

1.  Selection and characteristics of a Vibrio cholerae mutant lacking the A (ADP-ribosylating) portion of the cholera enterotoxin.

Authors:  T Honda; R A Finkelstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

Review 2.  New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development.

Authors:  M M Levine; J B Kaper; R E Black; M L Clements
Journal:  Microbiol Rev       Date:  1983-12

3.  Study of epitopes of cholera enterotoxin-related enterotoxins by checkerboard immunoblotting.

Authors:  M Kazemi; R A Finkelstein
Journal:  Infect Immun       Date:  1990-07       Impact factor: 3.441

4.  Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR.

Authors:  V L Miller; J J Mekalanos
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

5.  Vibrio cholerae expresses iron-regulated outer membrane proteins in vivo.

Authors:  C V Sciortino; R A Finkelstein
Journal:  Infect Immun       Date:  1983-12       Impact factor: 3.441

6.  A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae.

Authors:  D Ewen Cameron; Jonathan M Urbach; John J Mekalanos
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-23       Impact factor: 11.205

7.  Correlation between intestinal synthesis of specific immunoglobulin A and protection against experimental cholera in mice.

Authors:  A Svennerholm; S Lange; J Holmgren
Journal:  Infect Immun       Date:  1978-07       Impact factor: 3.441
  7 in total

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