Literature DB >> 7829393

Suppression of G1 arrest and enhancement of G2 arrest by inhibitors of poly(ADP-ribose) polymerase: possible involvement of poly(ADP-ribosyl)ation in cell cycle arrest following gamma-irradiation.

T Nozaki1, M Masutani, T Akagawa, T Sugimura, H Esumi.   

Abstract

Low-dose gamma-irradiation of mouse embryonic fibroblast C3D2F1 3T3-a cells caused G1 arrest along with G2 arrest and inhibition of replicative DNA synthesis. When the cells were cultured in the presence of inhibitors of poly(ADP-ribose) polymerase [EC 2.4.2.30], such as 3-aminobenzamide, benzamide and luminol, G1 arrest of C3D2F1 3T3-a cells was suppressed and enhancement of G2 arrest was observed. In contrast, 3-aminobenzoic acid, a non-inhibitory analog of 3-aminobenzamide, did not suppress G1 arrest following gamma-irradiation. These results suggest that the poly(ADP-ribosyl)ation reaction is critical for the pathway of G1 arrest and is also involved in the pathway of G2 arrest.

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Year:  1994        PMID： 7829393      PMCID： PMC5919371          DOI： 10.1111/j.1349-7006.1994.tb02912.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


poly(ADP‐ribose) polymerase bromodeoxyuridine fluorescein isothiocyanate
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