Literature DB >> 7829059

Multiple loci affect genetic predisposition to hepatocarcinogenesis in mice.

G Manenti1, G Binelli, M Gariboldi, F Canzian, L De Gregorio, F S Falvella, T A Dragani, M A Pierotti.   

Abstract

The C3H/He mouse represents a good experimental model of genetic predisposition to hepatocellular tumor development. We analyzed an interspecific test-cross population of 106 urethane-treated male (C3H/He x Mus spretus) x C57BL/6J mice, typed with 222 genetic markers to locate precisely the hepatocellular tumor susceptibility (Hcs) loci. Three regions, on chromosomes 2, 5, and 19, showed a significant linkage with hepatocellular tumor development, as indicated by different quantitative indexes estimating liver tumor size. Liver tumor frequency was not genetically controlled. These loci are different from three other Hcs loci that we have previously mapped in an F2 progeny of the C3H/He mouse crossed with the resistant laboratory strain A/J. The present result indicates a multigenic model of inheritance for hepatocellular tumor susceptibility.

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Year:  1994        PMID： 7829059     DOI： 10.1006/geno.1994.1466

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  20 in total

1.  Two genes abrogate the inhibition of murine hepatocarcinogenesis by ovarian hormones.

Authors:  T M Poole; N R Drinkwater
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

2.  The placenta growth factor gene of the mouse.

Authors:  T DiPalma; M Tucci; G Russo; D Maglione; C T Lago; A Romano; S Saccone; G Della Valle; L De Gregorio; T A Dragani; G Viglietto; M G Persico
Journal:  Mamm Genome       Date:  1996-01       Impact factor: 2.957

3.  Generation and mapping of Mus spretus strain-specific markers for rapid genomic scanning.

Authors:  R Elango; L Riba; D Housman; K Hunter
Journal:  Mamm Genome       Date:  1996-05       Impact factor: 2.957

4.  Genetic mapping of the homeobox-containing gene Otxl gene on mouse Chromosome 11.

Authors:  L De Gregorio; G Manenti; A Simeone; T A Dragani
Journal:  Mamm Genome       Date:  1996-03       Impact factor: 2.957

5.  Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes.

Authors:  G Liguori; L De Gregorio; M Tucci; C T Lago; A Barra; T A Dragani; M Persico
Journal:  Mamm Genome       Date:  1997-07       Impact factor: 2.957

6.  Genetic mapping of the vascular endothelial growth factor (Vegf) gene to mouse chromosome 17.

Authors:  L De Gregorio; V Vincenti; G Breier; A Damert; T A Dragani; M G Persico
Journal:  Mamm Genome       Date:  1997-06       Impact factor: 2.957

7.  Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease.

Authors:  Drazen B Zimonjic; Veronika Ullmannova-Benson; Valentina M Factor; Snorri S Thorgeirsson; Nicholas C Popescu
Journal:  Cancer Genet Cytogenet       Date:  2009-05

8.  A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.

Authors:  Andrea Bilger; L Michelle Bennett; Reynaldo A Carabeo; Teresa A Chiaverotti; Cecily Dvorak; Kristin M Liss; Susan A Schadewald; Henry C Pitot; Norman R Drinkwater
Journal:  Genetics       Date:  2004-06       Impact factor: 4.562

9.  Chromosome mapping of nine tropomyosin-related sequences in mice.

Authors:  M Gariboldi; G Manenti; T A Dragani; M A Pierotti
Journal:  Mamm Genome       Date:  1995-04       Impact factor: 2.957

10.  Interaction of major genes predisposing to hepatocellular carcinoma with genes encoding signal transduction pathways influences tumor phenotype and prognosis.

Authors:  Francesco Feo; Maddalena Frau; Rosa-Maria Pascale
Journal:  World J Gastroenterol       Date:  2008-11-21       Impact factor: 5.742
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