| Literature DB >> 7828717 |
Y H Lee1, H J Lee, S J Lee, D S Min, S H Baek, Y S Kim, S H Ryu, P G Suh.
Abstract
Phospholipase C (PLC)-gamma 1 and -gamma 2 play a pivotal role in signal transduction for cell proliferation and differentiation. The enzyme activity and protein level of PLC-gamma 1 were markedly decreased in the human histiocytic leukemia U937 cell line during the differentiation process which is induced by phorbol 12-myristate 13-acetate (PMA) but those of PLC-gamma 2 were not altered. Northern blot analysis showed that the levels of PLC-gamma 1 and -gamma 2 transcripts were not changed. These results suggest that the expression of PLC-gamma 1 during the PMA-induced differentiation may be down-regulated by post-transcriptional processing.Entities:
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Year: 1995 PMID： 7828717 DOI： 10.1016/0014-5793(94)01404-o
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124