Literature DB >> 7828626

Indium-111 labelled pooled human immunoglobulin imaging to monitor the efficacy of specific therapy for Pneumocystis carinii pneumonia.

J R Buscombe1, I Khalkhali, G R Mason, D Rauh, J Meatherall, W J Oyen, F H Corstens.   

Abstract

Functional imaging is ideally suited to monitoring the effect of specific therapy on disease processes. In this pilot study five patients with AIDS and Pneumocystis carinii pneumonia (PCP) were imaged with Indium-111 labelled pooled human immunoglobulin (111In-HIG) during infection and after therapy for PCP. The lung activity of 111In-HIG, measured as a lung/heart ratio, was calculated in a study performed during infection with PCP and after therapy. In all five patients the lung/heart ratio of 111In-HIG was reduced after treatment. The mean reduction in heart/lung ratio was 27% (range 12%-53%). If these results are confirmed by a larger study, 111In-HIG will be useful in monitoring the response of PCP to therapy in patients with AIDS.

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Year:  1994        PMID： 7828626     DOI： 10.1007/bf00181072

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  9 in total

1.  Imaging of Pneumocystis carinii pneumonia with 111In-labelled non-specific polyclonal IgG: an experimental study in rats.

Authors:  J A Fishman; H W Strauss; A J Fischman; M Nedelman; R Callahan; B A Khaw; R H Rubin
Journal:  Nucl Med Commun       Date:  1991-03       Impact factor: 1.690

2.  Projections of AIDS morbidity and mortality in San Francisco.

Authors:  G F Lemp; S F Payne; G W Rutherford; N A Hessol; W Winkelstein; J A Wiley; A R Moss; R E Chaisson; R T Chen; D W Feigal
Journal:  JAMA       Date:  1990-03-16       Impact factor: 56.272

3.  Pneumocystis carinii pneumonia: spectrum of parenchymal CT findings.

Authors:  J E Kuhlman; M Kavuru; E K Fishman; S S Siegelman
Journal:  Radiology       Date:  1990-06       Impact factor: 11.105

4.  Diagnostic implications of Ga-67 chest-scan patterns in human immunodeficiency virus-seropositive patients.

Authors:  E L Kramer; J H Sanger; S M Garay; R J Grossman; S Tiu; H Banner
Journal:  Radiology       Date:  1989-03       Impact factor: 11.105

5.  111-indium-DTPA-IgG lung imaging in patients with pulmonary and HIV infection.

Authors:  I Khalkhali; I Mena; D A Rauh; L E Diggles; H L Pham; G R Mason
Journal:  Chest       Date:  1995-05       Impact factor: 9.410

6.  Indium-111-labeled polyclonal human immunoglobulin: identifying focal infection in patients positive for human immunodeficiency virus.

Authors:  J R Buscombe; W J Oyen; A Grant; R A Claessens; J van der Meer; F H Corstens; P J Ell; R F Miller
Journal:  J Nucl Med       Date:  1993-10       Impact factor: 10.057

7.  Patterns of gallium-67 scintigraphy in patients with acquired immunodeficiency syndrome and the AIDS related complex.

Authors:  J Bitran; C Bekerman; R Weinstein; C Bennett; U Ryo; S Pinsky
Journal:  J Nucl Med       Date:  1987-07       Impact factor: 10.057

8.  Pulmonary manifestations of AIDS: review of 106 episodes.

Authors:  B Suster; M Akerman; M Orenstein; M R Wax
Journal:  Radiology       Date:  1986-10       Impact factor: 11.105

9.  Changing disease patterns in patients with AIDS in a referral centre in the United Kingdom: the changing face of AIDS.

Authors:  B S Peters; E J Beck; D G Coleman; M J Wadsworth; O McGuinness; J R Harris; A J Pinching
Journal:  BMJ       Date:  1991-01-26
  9 in total
  1 in total

1.  Serial indium-111-labelled IgG biodistribution in rat Pneumocystis carinii pneumonia: a tool to monitor the course and severity of the infection.

Authors:  R M Perenboom; W J Oyen; A C van Schijndel; P Beckers; F H Corstens; J W van der Meer
Journal:  Eur J Nucl Med       Date:  1995-10
  1 in total

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