Literature DB >> 7828188

Neuropeptides in migraine and cluster headache.

L Edvinsson1, P J Goadsby.   

Abstract

The cerebral circulation is invested by a rich network of neuropeptide Y (NPY) and noradrenaline containing sympathetic nerve fibers in arteries, arterioles and veins. However, the nerve supply of vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) containing fibers is sparse. While noradrenaline and NPY cause vasoconstriction, VIP, SP and CGRP are potent vasodilators. Stimulation of the trigeminal ganglion in cat and man elicits release of SP and CGRP. Subjects with spontaneous attacks of migraine show release of CGRP in parallel with headache. Cluster headache patients have release of CGRP and VIP during bouts. Treatment with sumatriptan aborts headache in migraine and cluster headache as well as the concomitant peptide release.

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Year:  1994        PMID： 7828188     DOI： 10.1046/j.1468-2982.1994.1405320.x

Source DB:  PubMed          Journal:  Cephalalgia        ISSN： 0333-1024            Impact factor:   6.292


  37 in total

1.  Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide.

Authors:  Thomas Denekas; Markus Tröltzsch; Axel Vater; Sven Klussmann; Karl Messlinger
Journal:  Br J Pharmacol       Date:  2006-04-24       Impact factor: 8.739

2.  Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models.

Authors:  Amanda Avona; Carolina Burgos-Vega; Michael D Burton; Armen N Akopian; Theodore J Price; Gregory Dussor
Journal:  J Neurosci       Date:  2019-04-08       Impact factor: 6.167

3.  Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery.

Authors:  L Edvinsson; E Nilsson; I Jansen-Olesen
Journal:  Br J Pharmacol       Date:  2007-01-22       Impact factor: 8.739

Review 4.  Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraine.

Authors:  Paul L Durham
Journal:  Headache       Date:  2008-09       Impact factor: 5.887

5.  Chronic Daily Headache: Theory to Therapy.

Authors: 
Journal:  Curr Rev Pain       Date:  1999

6.  Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.

Authors:  Paul L Durham; Carrie V Vause
Journal:  CNS Drugs       Date:  2010-07       Impact factor: 5.749

Review 7.  The extracranial vascular theory of migraine: an artificial controversy.

Authors:  Elliot Shevel
Journal:  J Neural Transm (Vienna)       Date:  2011-01-05       Impact factor: 3.575

8.  Repression of calcitonin gene-related peptide expression in trigeminal neurons by a Theobroma cacao extract.

Authors:  Marcie J Abbey; Vinit V Patil; Carrie V Vause; Paul L Durham
Journal:  J Ethnopharmacol       Date:  2007-10-05       Impact factor: 4.360

9.  Prophylactic activity of increasing doses of intravenous histamine in refractory migraine: Retrospective observations of a series of patients with migraine without aura.

Authors:  Umberto Pietrini; Massimo De Luca; Enrico Del Bene; Francesco De Cesaris; Luca Bertinotti; Nicola Colangelo; Alberto Moggi Pignone
Journal:  Curr Ther Res Clin Exp       Date:  2004-01

10.  Stimulation of the calcitonin gene-related peptide enhancer by mitogen-activated protein kinases and repression by an antimigraine drug in trigeminal ganglia neurons.

Authors:  Paul L Durham; Andrew F Russo
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167
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