OBJECTIVE: To determine whether low birth weight and low weight at 1 year are followed by an increased prevalence of coronary heart disease in adult life. DESIGN: A follow up study of men born during 1920-30 whose birth weights and weights at 1 year were recorded. SETTING: Hertfordshire, England. SUBJECTS: 290 men born and still living in East Hertfordshire. MAIN OUTCOME MEASURE: The prevalence of coronary heart disease, defined by the Rose/WHO chest pain questionnaire, standard electrocardiographic criteria, or history of coronary artery angioplasty or graft surgery. RESULTS: 42 (14%) men had coronary heart disease. Their mean birth weight, 7.9 lb (3600 g), was the same as that of the other men. Their mean weight at 1 year, 21.8 lb (9.9 kg), was 1 lb (454 g) lower (95% confidence interval 0.1 to 1.8, P = 0.02). Percentages of men with coronary heart disease fell from 27% in those who weighed 18 lb (8.2 kg) or less at 1 year to 9% in those who weighed more than 26 lb (11.8 kg) (P value for trend = 0.03). This trend occurred in both smokers and non-smokers and within each social class. CONCLUSION: These findings add to the evidence that coronary heart disease is "programmed" during early growth.
OBJECTIVE: To determine whether low birth weight and low weight at 1 year are followed by an increased prevalence of coronary heart disease in adult life. DESIGN: A follow up study of men born during 1920-30 whose birth weights and weights at 1 year were recorded. SETTING: Hertfordshire, England. SUBJECTS: 290 men born and still living in East Hertfordshire. MAIN OUTCOME MEASURE: The prevalence of coronary heart disease, defined by the Rose/WHO chest pain questionnaire, standard electrocardiographic criteria, or history of coronary artery angioplasty or graft surgery. RESULTS: 42 (14%) men had coronary heart disease. Their mean birth weight, 7.9 lb (3600 g), was the same as that of the other men. Their mean weight at 1 year, 21.8 lb (9.9 kg), was 1 lb (454 g) lower (95% confidence interval 0.1 to 1.8, P = 0.02). Percentages of men with coronary heart disease fell from 27% in those who weighed 18 lb (8.2 kg) or less at 1 year to 9% in those who weighed more than 26 lb (11.8 kg) (P value for trend = 0.03). This trend occurred in both smokers and non-smokers and within each social class. CONCLUSION: These findings add to the evidence that coronary heart disease is "programmed" during early growth.
Authors: P Nafstad; J J Jaakkola; J A Hagen; B S Pedersen; E Qvigstad; G Botten; J Kongerud Journal: J Epidemiol Community Health Date: 1997-06 Impact factor: 3.710
Authors: Graeme R Polglase; Beth J Allison; Elise Coia; Anqi Li; Graham Jenkin; Atul Malhotra; Arvind Sehgal; Martin Kluckow; Andrew W Gill; Stuart B Hooper; Suzanne L Miller Journal: Pediatr Res Date: 2016-05-16 Impact factor: 3.756