Ontogeny of tyrosine hydroxylase levels in the neuropil close to locus caeruleus.

We aimed to characterize tyrosine hydroxylase (TH) expression within the pericaerulean area (PCA) during postnatal development. Levels of TH along the caudorostral axis of the locus caeruleus (LC) showed a dramatic increase in the PCA beyond day 21. This was due to the extension of the TH-containing area, particularly organized in the ventrolateral and longitudinal directions. As dendrites of LC neurones were observed at long distances within this PCA, such an increase in TH distribution could affect functions related to the LC.