| Literature DB >> 7825989 |
N Hood1, M C Chan, S M Maxwell, J B Familusi, C A Hart.
Abstract
The aim of this study was to assess the efficacy of the tetanus toxoid immunization programme in Nigeria, specifically the placental transfer of antibody to newborn Nigerian babies. Tetanus toxoid antibody levels were measured in 39 mother-baby pairs in Ibadan, Nigeria and compared with 78 British mother-baby pairs. Geometric means of the ratios of cord/mother (sequestration index SI) were 0.776 for Nigerian pairs and 1.306 for British pairs, indicating a limitation in the placental transfer of tetanus toxoid in the Nigerian population. These findings confirm that there is a block in the placental transfer of anti-tetanus toxoid antibodies in African populations which will affect current immunization programmes and requires further investigation.Entities:
Keywords: Africa; Africa South Of The Sahara; Antibodies; Biology; Comparative Studies; Delivery Of Health Care; Developed Countries; Developing Countries; Diseases; English Speaking Africa; Europe; Fetal Membranes; Fetus; Health; Health Services; Immunity; Immunization; Immunologic Factors; Infections; Maternal-fetal Exchange; Nigeria; Northern Europe; Organization And Administration; Physiology; Pregnancy; Primary Health Care; Program Effectiveness; Program Evaluation; Programs; Reproduction; Research Methodology; Research Report; Studies; Tetanus--prevention and control; United Kingdom; Western Africa
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Year: 1994 PMID： 7825989 DOI： 10.1080/02724936.1994.11747714
Source DB: PubMed Journal: Ann Trop Paediatr ISSN： 0272-4936