Literature DB >> 7825347

Toxicity of new spinal agents.

J G Collins1.   

Abstract

The clinical success of perispinal administration of opiates for pain relief has demonstrated the power of manipulating the neurochemistry of the spinal cord. This article briefly discussed reasons for increased interest in new spinal agents and some of the issues associated with determining their clinical safety.

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Year:  1993        PMID： 7825347      PMCID： PMC2588888     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN： 0044-0086


  13 in total

1.  Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists.

Authors:  Tony L Yaksh
Journal:  Pain       Date:  1989-04       Impact factor: 6.961

2.  Effects of phenoperidine on lamina V cells in the cat dorsal horn.

Authors:  J M Besson; M C Wyon-Maillard; J M Benoist; C Conseiller; K F Hamann
Journal:  J Pharmacol Exp Ther       Date:  1973-11       Impact factor: 4.030

3.  Effects of morphine and naloxone on dorsal horn neurones in the cat.

Authors:  O Calvillo; J L Henry; R S Neuman
Journal:  Can J Physiol Pharmacol       Date:  1974-12       Impact factor: 2.273

4.  Lamina-specific suppression of dorsal-horn unit activity by morphine sulfate.

Authors:  L M Kitahata; Y Kosaka; A Taub; K Bonikos; M Hoffert
Journal:  Anesthesiology       Date:  1974-07       Impact factor: 7.892

5.  Myelinated afferents signal the hyperalgesia associated with nerve injury.

Authors:  James N Campbell; Srinivasa N Raja; Richard A Meyer; Susan E Mackinnon
Journal:  Pain       Date:  1988-01       Impact factor: 6.961

6.  Antinociceptive effects and spinal cord tissue concentrations after intrathecal injection of guanfacine or clonidine into rats.

Authors:  C Post; T Gordh; B G Minor; T Archer; J Freedman
Journal:  Anesth Analg       Date:  1987-04       Impact factor: 5.108

7.  Epidural clonidine produces antinociception, but not hypotension, in sheep.

Authors:  J C Eisenach; D M Dewan; J C Rose; J M Angelo
Journal:  Anesthesiology       Date:  1987-04       Impact factor: 7.892

8.  Analgesia mediated by a direct spinal action of narcotics.

Authors:  T L Yaksh; T A Rudy
Journal:  Science       Date:  1976-06-25       Impact factor: 47.728

9.  Effect of epidural clonidine on spinal cord blood flow and regional and central hemodynamics in pigs.

Authors:  T Gordh; U Feuk; K Norlén
Journal:  Anesth Analg       Date:  1986-12       Impact factor: 5.108

10.  Evaluation of the toxicity of subarachnoid clonidine, guanfacine, and a substance P-antagonist on rat spinal cord and nerve roots: light and electron microscopic observations after chronic intrathecal administration.

Authors:  T Gordh; C Post; Y Olsson
Journal:  Anesth Analg       Date:  1986-12       Impact factor: 5.108
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