Literature DB >> 7824173

Human cortical neuronal (HCN) cell lines: a model for amyloid beta neurotoxicity.

Z Zhang1, G J Drzewiecki, J T Hom, P C May, P A Hyslop.   

Abstract

Human cortical neuronal cell lines HCN-1A and HCN-2 are killed for following exposure of the differentiated cells to amyloid beta-peptide(1-40), a component of senile plaques and other amyloid deposits in brains from Alzheimer's patients. We present a model of A beta toxicity uncomplicated by the presence of other cell types that can be used to address the mechanism of A beta neurotoxicity. This model will be useful in the evaluation of neuroprotective compounds which may attenuate cortical neuronal loss in Alzheimer's disease.

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Year:  1994        PMID： 7824173     DOI： 10.1016/0304-3940(94)90892-3

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

1.  Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.

Authors:  M A Pappolla; M Sos; R A Omar; R J Bick; D L Hickson-Bick; R J Reiter; S Efthimiopoulos; N K Robakis
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

Review 2.  The toxicity in vitro of beta-amyloid protein.

Authors:  L L Iversen; R J Mortishire-Smith; S J Pollack; M S Shearman
Journal:  Biochem J       Date:  1995-10-01       Impact factor: 3.857

3.  Nicotinamide protects HCN2 cells from the free radical generating toxin, tertiary butylhydroperoxide (t-BuOOH).

Authors:  Manisha Sonee; Johanna R. Martens; Suman K. Mukherjee
Journal:  Neurotox Res       Date:  2002 Nov-Dec       Impact factor: 3.911

4.  DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different.

Authors:  Lee J Martin; Qing Chang
Journal:  J Neuropathol Exp Neurol       Date:  2018-07-01       Impact factor: 3.685

5.  Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

Authors:  W A Pedersen; M A Kloczewiak; J K Blusztajn
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

6.  Tumor necrosis factor alpha regulates responses to nerve growth factor, promoting neural cell survival but suppressing differentiation of neuroblastoma cells.

Authors:  Yoshinori Takei; Ronald Laskey
Journal:  Mol Biol Cell       Date:  2007-12-19       Impact factor: 4.138

7.  Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease.

Authors:  Miklos Jaszberenyi; Ferenc G Rick; Luca Szalontay; Norman L Block; Marta Zarandi; Ren-Zhi Cai; Andrew V Schally
Journal:  Aging (Albany NY)       Date:  2012-11       Impact factor: 5.682

8.  Effect of photobiomodulation therapy on neuronal injuries by ouabain: the regulation of Na, K-ATPase; Src; and mitogen-activated protein kinase signaling pathway.

Authors:  Yun-Hee Rhee; Jeong Hwan Moon; Jae Yun Jung; Connie Oh; Jin-Chul Ahn; Phil-Sang Chung
Journal:  BMC Neurosci       Date:  2019-04-26       Impact factor: 3.288
  8 in total

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