Literature DB >> 7824037

5-Hydroxytryptamine (5-HT) and the initiation of migraine: new perspectives.

J R Fozard1, H O Kalkman.   

Abstract

The hypothesis that 5-hydroxytryptamine (5-HT) acting through 5-HT2C receptors is a key factor in the initiation of migraine has been re-evaluated in the light of recent basic and clinical scientific developments. The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/5-HT2C receptor is a neurochemical feature predisposing to headache. Taken together the data bring new perspectives to the role of 5-HT acting through 5-HT2C (or closely similar) receptors in the initiation of migraine.

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Year:  1994        PMID： 7824037     DOI： 10.1007/bf00175026

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  44 in total

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Journal:  Ann N Y Acad Sci       Date:  1990       Impact factor: 5.691

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Journal:  Psychiatry Res       Date:  1990-08       Impact factor: 3.222

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Journal:  Eur J Pharmacol       Date:  1992-02-11       Impact factor: 4.432

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Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

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Journal:  Clin Pharmacol Ther       Date:  1988-06       Impact factor: 6.875

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Authors:  M L Cohen; L A Wittenauer
Journal:  Life Sci       Date:  1986-01-06       Impact factor: 5.037

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Authors:  M J Sumner
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739

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Authors:  S R Hughes; S D Brain
Journal:  Br J Pharmacol       Date:  1994-02       Impact factor: 8.739
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  16 in total

Review 1.  The clinical potential of endothelin receptor antagonists in cardiovascular medicine.

Authors:  C J Ferro; D J Webb
Journal:  Drugs       Date:  1996-01       Impact factor: 9.546

2.  Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles.

Authors:  A Elhusseiny; E Hamel
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

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Authors:  E Glusa; A Roos
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

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Authors:  Matthew W Johnson; R Andrew Sewell; Roland R Griffiths
Journal:  Drug Alcohol Depend       Date:  2011-11-29       Impact factor: 4.492

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Authors:  Geoffrey Andrew Lambert; Cathy Donaldson; Karen Lisa Hoskin; Peter Michael Boers; Alessandro Stefano Zagami
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-05-07       Impact factor: 3.000

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Authors:  Raphaela Verheggen; Andreas Meier; Inga Werner; Andreas Wienekamp; Thomas Kruschat; Trond Brattelid; Finn Olav Levy; Alberto Kaumann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-03-06       Impact factor: 3.000

Review 7.  Current and prospective pharmacological targets in relation to antimigraine action.

Authors:  Suneet Mehrotra; Saurabh Gupta; Kayi Y Chan; Carlos M Villalón; David Centurión; Pramod R Saxena; Antoinette MaassenVanDenBrink
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-07-15       Impact factor: 3.000

Review 8.  Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications.

Authors:  Carlos M Villalón; David Centurión
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-08-17       Impact factor: 3.000

Review 9.  The role of nitric oxide in vascular headache.

Authors:  Paul-Hugo M van der Kuy; Joseph J Lohman
Journal:  Pharm World Sci       Date:  2003-08

10.  Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs.

Authors:  R Verheggen; S Freudenthaler; F Meyer-Dulheuer; A J Kaumann
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739
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