Literature DB >> 7823521

[The COMOD system. A preservative-free multidose container for eyedrops].

C Teping1, B Wiedemann.   

Abstract

BACKGROUND: The newly developed COMOD -system is a multi-dose-container for eye drops which makes the addition of preservatives unnecessary. In this study we investigated the microbiological safety of the COMOD -system which was used in action for the first time.
METHODS: After cataract surgery 97 patients only used unpreserved, dexamethason-containing eye drops in COMOD -bottles for two days in hospital and for five more days at home. The used bottle were examined microbiologically afterwards.
RESULTS: No COMOD -bottle showed a microbiologically serious contamination; no patient showed an unusual healing process which would have been typical for any infection. Concerning the handling it turned out during use in hospital that the hand-made prototypes have to be improves. The vast majority of patients managed the handling at home well, independent of sex or age.
CONCLUSION: The COMOD -system is a suitable microbiologically safe container for unpreserved eye drops.

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Year:  1994        PMID: 7823521     DOI: 10.1055/s-2008-1045518

Source DB:  PubMed          Journal:  Klin Monbl Augenheilkd        ISSN: 0023-2165            Impact factor:   0.700


  3 in total

1.  To preserve or not to preserve, is that the question?

Authors:  L A Wilson
Journal:  Br J Ophthalmol       Date:  1996-07       Impact factor: 4.638

2.  Multidose Preservative Free Eyedrops by Selective Removal of Benzalkonium Chloride from Ocular Formulations.

Authors:  Kuan-Hui Hsu; Karishma Gupta; Harish Nayaka; Aashrit Donthi; Siddarth Kaul; Anuj Chauhan
Journal:  Pharm Res       Date:  2017-10-24       Impact factor: 4.200

3.  Microbial contamination of preservative free eye drops in multiple application containers.

Authors:  M Q Rahman; D Tejwani; J A Wilson; I Butcher; K Ramaesh
Journal:  Br J Ophthalmol       Date:  2006-02       Impact factor: 4.638

  3 in total

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