N-methyl-D-aspartate receptors contribute to afferent synaptic transmission in the medial vestibular nucleus of young rats.

In the medial vestibular nucleus (MVN), the non-N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors has been reported as operating at synapses between ipsilateral vestibular afferents and neurons. In the present study, we addressed the question of whether or not NMDA receptors contribute to afferent synaptic transmission in the MVN and if so, to what degree. Using nystatin-perforated or conventional whole-cell patch clamp methods in brainstem slices of young rats (postnatal day 4-6), we found that NMDA receptors contribute to a substantial extent to afferent synaptic transmission in the MVN of young rats.