Literature DB >> 7820125

Nasal absorption of zidovudine and its transport to cerebrospinal fluid in rats.

T Seki1, N Sato, T Hasegawa, T Kawaguchi, K Juni.   

Abstract

The nasal absorption of zidovudine (AZT) and its subsequent transport to cerebrospinal fluid (CSF) was examined in rats. Both rapid absorption and a high CSF concentration were observed after the nasal application. Plasma and CSF concentrations of AZT increased when probenecid was coadministered with AZT. Thus, this nasal coadministration of AZT and probenecid could be useful for the treatment of AIDS patients with neuropathies.

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Year:  1994        PMID： 7820125     DOI： 10.1248/bpb.17.1135

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  11 in total

1.  Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain.

Authors:  Mansi Krishan; Gary A Gudelsky; Pankaj B Desai; Mary Beth Genter
Journal:  Drug Deliv       Date:  2013-10-14       Impact factor: 6.419

2.  Pharmacokinetic Interaction between Naloxone and Naltrexone Following Intranasal Administration to Healthy Subjects.

Authors:  Philip Krieter; C Nora Chiang; Shwe Gyaw; Phil Skolnick; Rebekah Snyder
Journal:  Drug Metab Dispos       Date:  2019-04-16       Impact factor: 3.922

3.  Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb.

Authors:  Mary Beth Genter; Mansi Krishan; Lisa M Augustine; Nathan J Cherrington
Journal:  Drug Metab Dispos       Date:  2010-07-21       Impact factor: 3.922

4.  Demonstration of Nucleoside Transporter Activity in the Nose-to-Brain Distribution of [18F]Fluorothymidine Using PET Imaging.

Authors:  Laura L Boles Ponto; Jiangeng Huang; Susan A Walsh; Michael R Acevedo; Christine Mundt; John Sunderland; Maureen Donovan
Journal:  AAPS J       Date:  2017-12-07       Impact factor: 4.009

5.  Kinetics of quinolone antibiotics in rats: efflux from cerebrospinal fluid to the circulation.

Authors:  T Ooie; H Suzuki; T Terasaki; Y Sugiyama
Journal:  Pharm Res       Date:  1996-07       Impact factor: 4.200

6.  Different distribution of morphine and morphine-6 beta-glucuronide after intracerebroventricular injection in rats.

Authors:  Takashi Okura; Masanori Saito; Misato Nakanishi; Noriyuki Komiyama; Aki Fujii; Shizuo Yamada; Ryohei Kimura
Journal:  Br J Pharmacol       Date:  2003-08-04       Impact factor: 8.739

7.  P-Glycoprotein attenuates brain uptake of substrates after nasal instillation.

Authors:  Candace L Graff; Gary M Pollack
Journal:  Pharm Res       Date:  2003-08       Impact factor: 4.200

Review 8.  Antiretroviral bioanalysis methods of tissues and body biofluids.

Authors:  Robin DiFrancesco; Getrude Maduke; Rutva Patel; Charlene R Taylor; Gene D Morse
Journal:  Bioanalysis       Date:  2013-02       Impact factor: 2.681

9.  Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery: studies in rats and comparison with a human study.

Authors:  Mascha P van den Berg; Paul Merkus; Stefan G Romeijn; J Coos Verhoef; Frans W H M Merkus
Journal:  Pharm Res       Date:  2004-05       Impact factor: 4.200

10.  Pharmacokinetic and pharmacodynamic interaction between allopurinol and probenecid in healthy subjects.

Authors:  Sophie L Stocker; Kenneth M Williams; Andrew J McLachlan; Garry G Graham; Richard O Day
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447
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