A comparative study of daily and twice-weekly continuation regimens of tuberculosis chemotherapy, including a comparison of two durations of sanatorium treatment.

Further results are presented of a controlled clinical trial carried out in Czechoslovakia of chemotherapeutic regimens in pulmonary tuberculosis in which, following 3 months of standard triple chemotherapy, 3 continuation regimens allocated at random for up to 18 or 24 months were compared. These were PAS plus isoniazid daily, streptomycin plus isoniazid twice a week and streptomycin plus isoniazid twice a week up to 1 year and then streptomycin plus isoniazid once a week. After 3 years the results of all 3 continuation regimens were highly satisfactory and it was concluded that they were equally effective, but that the intermittent regimens have the advantage of stricter control over the patient's chemotherapy.

RCT Entities:   Population Interventions Outcomes