Literature DB >> 7819053

Lymphomas with testicular localisation show a consistent BCL-2 expression without a translocation (14;18): a molecular and immunohistochemical study.

A C Lambrechts1, L H Looijenga, M B van't Veer, J van Echten, W Timens, J W Oosterhuis.   

Abstract

The presence of the BCL-2 protein was studied in nine non-Hodgkin's lymphomas with testicular localisation. A consistent presence of the BCL-2 protein was found. The chromosomal translocation (14;18) was seen neither by cytogenetic analysis (n = 4) nor by polymerase chain reaction amplification and Southern blotting (n = 9). Therefore, this translocation is not responsible for the presence of the BCL-2 protein in non-Hodgkin's lymphomas with testicular localisation. We suggest that the presence of the BCL-2 protein in these lymphomas is related to the differentiation stage of the B-lymphocytes or may play a role in the pathogenesis of these lymphomas. The consistent finding of the BCL-2 protein in lymphomas with testicular localisation may support the clinical observation that these lymphomas are a separate entity.

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Year:  1995        PMID： 7819053      PMCID： PMC2033440          DOI： 10.1038/bjc.1995.15

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  27 in total

Review 1.  Bcl-2 initiates a new category of oncogenes: regulators of cell death.

Authors:  S J Korsmeyer
Journal:  Blood       Date:  1992-08-15       Impact factor: 22.113

2.  Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.

Authors:  S Henderson; M Rowe; C Gregory; D Croom-Carter; F Wang; R Longnecker; E Kieff; A Rickinson
Journal:  Cell       Date:  1991-06-28       Impact factor: 41.582

3.  BCL-2 gene rearrangements in malignant B cell lymphomas.

Authors:  H Griesser; K Lennert
Journal:  Br J Haematol       Date:  1990-05       Impact factor: 6.998

4.  Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

Authors:  G Nuñez; L London; D Hockenbery; M Alexander; J P McKearn; S J Korsmeyer
Journal:  J Immunol       Date:  1990-05-01       Impact factor: 5.422

5.  The bcl-2 gene is rearranged in many diffuse B-cell lymphomas.

Authors:  A C Aisenberg; B M Wilkes; J O Jacobson
Journal:  Blood       Date:  1988-04       Impact factor: 22.113

Review 6.  The 14;18 translocation in European cases of follicular lymphoma: comparison of Southern blotting and the polymerase chain reaction.

Authors:  F Pezzella; E Ralfkiaer; K C Gatter; D Y Mason
Journal:  Br J Haematol       Date:  1990-09       Impact factor: 6.998

7.  Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

Authors:  F Pezzella; A G Tse; J L Cordell; K A Pulford; K C Gatter; D Y Mason
Journal:  Am J Pathol       Date:  1990-08       Impact factor: 4.307

8.  Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.

Authors:  D Hockenbery; G Nuñez; C Milliman; R D Schreiber; S J Korsmeyer
Journal:  Nature       Date:  1990-11-22       Impact factor: 49.962

9.  Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.

Authors:  D L Vaux; S Cory; J M Adams
Journal:  Nature       Date:  1988-09-29       Impact factor: 49.962

10.  Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t(14;18) chromosomal translocation.

Authors:  B Y Ngan; Z Chen-Levy; L M Weiss; R A Warnke; M L Cleary
Journal:  N Engl J Med       Date:  1988-06-23       Impact factor: 91.245
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  3 in total

Review 1.  Lymphoma of the testis as primary location: tumour review.

Authors:  Georgios Koukourakis; Vassilios Kouloulias
Journal:  Clin Transl Oncol       Date:  2010-05       Impact factor: 3.405

2.  Rapid detection of IgH/BCL2 rearrangement in follicular lymphoma by interphase fluorescence in situ hybridization with bacterial artificial chromosome probes.

Authors:  Feng Jiang; Fan Lin; Roger Price; Jun Gu; L Jeffrey Medeiros; Hua Z Zhang; Su-Su Xie; Nancy P Caraway; Ruth L Katz
Journal:  J Mol Diagn       Date:  2002-08       Impact factor: 5.568

3.  Analysis of chromosomal copy number changes and oncoprotein expression in primary central nervous system lymphomas: frequent loss of chromosome arm 6q.

Authors:  Ronald Boonstra; Alice Koning; Mirjam Mastik; Anke van den Berg; Sibrand Poppema
Journal:  Virchows Arch       Date:  2003-06-12       Impact factor: 4.064
  3 in total

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