Literature DB >> 7819045

O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.

S Egyházi1, J Hansson, U Ringborg.   

Abstract

Tumour samples obtained from one primary melanoma and several lymph node and skin metastases were analysed for O6-methylguanine-DNA methyltransferase (MGMT) activity. While lymph node and skin metastases had similar average MGMT activity, the variance was significantly higher in lymph node metastases. Variability in MGMT activity was frequently observed in different metastases in the same individual and to a lesser extent within metastases.

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Year:  1995        PMID： 7819045      PMCID： PMC2033437          DOI： 10.1038/bjc.1995.8

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  24 in total

1.  Adaptive response to alkylating agents involves alteration in situ of O6-methylguanine residues in DNA.

Authors:  P Karran; T Lindahl; B Griffin
Journal:  Nature       Date:  1979-07-05       Impact factor: 49.962

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs.

Authors:  B Myrnes; K E Giercksky; H Krokan
Journal:  Carcinogenesis       Date:  1983-12       Impact factor: 4.944

Review 4.  DTIC (NSC-45388) in malignant melanoma: a perspective.

Authors:  R L Comis
Journal:  Cancer Treat Rep       Date:  1976-02

5.  DNA crosslinking and cytotoxicity in normal and transformed human cells treated with antitumor nitrosoureas.

Authors:  L C Erickson; M O Bradley; J M Ducore; R A Ewig; K W Kohn
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

6.  Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains.

Authors:  R S Day; C H Ziolkowski; D A Scudiero; S A Meyer; A S Lubiniecki; A J Girardi; S M Galloway; G D Bynum
Journal:  Nature       Date:  1980-12-25       Impact factor: 49.962

7.  Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains.

Authors:  D B Yarosh; R S Foote; S Mitra; R S Day
Journal:  Carcinogenesis       Date:  1983       Impact factor: 4.944

8.  O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors.

Authors:  O Wiestler; P Kleihues; A E Pegg
Journal:  Carcinogenesis       Date:  1984-01       Impact factor: 4.944

9.  Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines.

Authors:  R Sklar; B Strauss
Journal:  Nature       Date:  1981-01-29       Impact factor: 49.962

10.  Developmental decline in DNA repair in neural retina cells of chick embryos. Persistent deficiency of repair competence in a cell line derived from late embryos.

Authors:  P Karran; A Moscona; B Strauss
Journal:  J Cell Biol       Date:  1977-07       Impact factor: 10.539
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  2 in total

Review 1.  Systemic therapy of malignant melanoma.

Authors:  J Hansson
Journal:  Med Oncol       Date:  1997-06       Impact factor: 3.064

2.  O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

Authors:  M R Middleton; J M Lunn; C Morris; G Rustin; S R Wedge; M H Brampton; M J Lind; S M Lee; D R Newell; N M Bleehen; E S Newlands; A H Calvert; G P Margison; N Thatcher
Journal:  Br J Cancer       Date:  1998-11       Impact factor: 7.640
  2 in total

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