OBJECTIVE: To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE). METHODS: MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLE patients and 136 controls. RESULTS: The MBP allele that is unable to activate complement was present in 42 SLE patients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLE patients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3). CONCLUSION: Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.
OBJECTIVE: To determine whether an allelic form of mannose-binding protein (MBP) incapable of activating complement is associated with susceptibility to systemic lupus erythematosus (SLE). METHODS:MBP allele frequencies were determined by amplification refractory mutation system-polymerase chain reaction in 102 white SLEpatients and 136 controls. RESULTS: The MBP allele that is unable to activate complement was present in 42 SLEpatients (41%) and in 41 controls (30%) (P = 0.08, odds ratio [OR] = 1.6, 95% confidence interval [95% CI] 1.0-2.8). The gene frequency of this allele was 0.25 in SLEpatients and 0.19 in controls (P = 0.08, OR = 1.5, 95% CI 1.0-2.3). CONCLUSION: Our results suggest that this allele of the MBP gene represents a minor risk factor for SLE.
Authors: S Saevarsdottir; H Kristjansdottir; G Grondal; T Vikingsdottir; K Steinsson; H Valdimarsson Journal: Ann Rheum Dis Date: 2006-01-26 Impact factor: 19.103
Authors: B P Tsao; R M Cantor; K C Kalunian; C J Chen; H Badsha; R Singh; D J Wallace; R C Kitridou; S L Chen; N Shen; Y W Song; D A Isenberg; C L Yu; B H Hahn; J I Rotter Journal: J Clin Invest Date: 1997-02-15 Impact factor: 14.808
Authors: Peter Garred; Morten A Nielsen; Jørgen A L Kurtzhals; Rajneesh Malhotra; Hans O Madsen; Bamenla Q Goka; Bartholomew D Akanmori; Robert B Sim; Lars Hviid Journal: Infect Immun Date: 2003-09 Impact factor: 3.441