Action of testosterone on the anti-müllerian activity of the chick embryonic testis assayed in vivo by organotypic grafting.

The implantation of embryonic testis grafts into female chick embryos induces the regression of their müllerian ducts (MDs) in a certain number of cases. The treatment of either the grafts or the grafted females with testosterone propionate (TP) results in a significant increase in the number of MD regressions observed. Our data are interpretable in terms of a direct activation by TP of the anti-müllerian activity of the embryonic testis. We discuss a possible mechanism accounting for the synergistic action of testosterone and anti-müllerian hormone.