Literature DB >> 7817398

Translational control of GCN4: an in vivo barometer of initiation-factor activity.

A G Hinnebusch1.   

Abstract

Phosphorylation of translation initiation factor-2 (eIF-2) is an adaptive mechanism for downregulating protein synthesis under conditions of starvation and stress. The yeast Saccharomyces has evolved a sophisticated means of increasing translation of GCN4 mRNA when eIF-2 is phosphorylated, allowing the induction of an important stress-response protein when expression of most other genes is decreasing. Because translation of GCN4 mRNA is so tightly coupled to eIF-2 activity, genetic analysis of this system has provided unexpected insights into the regulation of eIF-2 and its guanine nucleotide exchange factor, eIF-2B.

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Year:  1994        PMID： 7817398     DOI： 10.1016/0968-0004(94)90089-2

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  52 in total

1.  Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders.

Authors:  M Hemmings-Mieszczak; T Hohn; T Preiss
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

2.  YqjD is an inner membrane protein associated with stationary-phase ribosomes in Escherichia coli.

Authors:  Hideji Yoshida; Yasushi Maki; Shou Furuike; Akiko Sakai; Masami Ueta; Akira Wada
Journal:  J Bacteriol       Date:  2012-06-01       Impact factor: 3.490

3.  Qsr1p, a 60S ribosomal subunit protein, is required for joining of 40S and 60S subunits.

Authors:  D P Eisinger; F A Dick; B L Trumpower
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

4.  SQT1, which encodes an essential WD domain protein of Saccharomyces cerevisiae, suppresses dominant-negative mutations of the ribosomal protein gene QSR1.

Authors:  D P Eisinger; F A Dick; E Denke; B L Trumpower
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

5.  Autophagy and cell growth--the yin and yang of nutrient responses.

Authors:  Thomas P Neufeld
Journal:  J Cell Sci       Date:  2012-05-30       Impact factor: 5.285

6.  Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.

Authors:  M J Ruiz-Echevarria; S W Peltz
Journal:  EMBO J       Date:  1996-06-03       Impact factor: 11.598

7.  The major open reading frame of the beta2.7 transcript of human cytomegalovirus: in vitro expression of a protein posttranscriptionally regulated by the 5' region.

Authors:  G Bergamini; M Reschke; M C Battista; M C Boccuni; F Campanini; A Ripalti; M P Landini
Journal:  J Virol       Date:  1998-10       Impact factor: 5.103

8.  eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

Authors:  G D Pavitt; K V Ramaiah; S R Kimball; A G Hinnebusch
Journal:  Genes Dev       Date:  1998-02-15       Impact factor: 11.361

Review 9.  Ribosome regulation by the nascent peptide.

Authors:  P S Lovett; E J Rogers
Journal:  Microbiol Rev       Date:  1996-06

Review 10.  Multiple steps in the regulation of transcription-factor level and activity.

Authors:  C F Calkhoven; G Ab
Journal:  Biochem J       Date:  1996-07-15       Impact factor: 3.857
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