Literature DB >> 781623

Fluorescent 2'(3')-O-aminoacylnucleosides-acceptor substrates for ribosomal peptidyltransferase+.

S Chládek, D Ringer, E M Abraham.   

Abstract

2'(3')-O-L-Phenylalanylderivatives of fluorescent 1,N6-ethenoadenosine and 3,N4-ethenocytidine were prepared by chemical synthesis. Both compounds are good acceptor substrates in ribosomal peptidyltransferase reactions. Since these compounds cannot form Watson-Crick base pairs, the results indicate that the terminal aminoacyladenosine unit of AA-tRNA is bound to ribosomal protein on the acceptor site of peptidyltransferase and not to rRNA.

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Year:  1976        PMID： 781623      PMCID： PMC342981          DOI： 10.1093/nar/3.5.1215

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

1.  Structural requirements for puromycin inhibition of protein synthesis.

Authors:  D NATHANS; A NEIDLE
Journal:  Nature       Date:  1963-03-16       Impact factor: 49.962

2.  "Nonisomerizable" 2'-and 3'-O-aminoacyl dinucleoside phosphates. Chemical synthesis and acceptor activity in the ribosomal peptidyltransferase reaction.

Authors:  S Chládek; D Ringer; K Quiggle
Journal:  Biochemistry       Date:  1974-06-18       Impact factor: 3.162

3.  L-Phenylalanine esters of open-chain analog of adenosine as substrates for ribosomal peptidyl transferase.

Authors:  S Chládek; D Ringer; J Zemlicka
Journal:  Biochemistry       Date:  1973-12-04       Impact factor: 3.162

4.  Fluorescent adenosine and cytidine derivatives.

Authors:  J R Barrio; J A Secrist; N J Leonard
Journal:  Biochem Biophys Res Commun       Date:  1972-01-31       Impact factor: 3.575

5.  Affinity labelling of 23-S ribosomal RNA in the active centre of Escherichia coli peptidyl transferase.

Authors:  P Greenwell; R J Harris; R H Symons
Journal:  Eur J Biochem       Date:  1974-12-02

6.  Fluorescent modification of adenosine-containing coenzymes. Biological activities and spectroscopic properties.

Authors:  J A Secrist; J R Barrio; N J Leonard; G Weber
Journal:  Biochemistry       Date:  1972-09-12       Impact factor: 3.162

7.  Synthesis and properties of poly (1,N-6-ethenoadenylic acid) and poly (3,N-4-ethenocytidylic acid).

Authors:  B Janik; R G Sommer; M P Kotick; D P Wilson; J Erickson
Journal:  Physiol Chem Phys       Date:  1973

8.  Species responsible for the fluorescence of 1:N6-ethenoadenosine.

Authors:  R D Spencer; G Weber; G L Tolman; J R Barrio; N J Leonard
Journal:  Eur J Biochem       Date:  1974-06-15

9.  Nicotinamide 3,N4-ethenocytosine dinucleotide, an analog of nicotinamide adenine dinucleotide. Synthesis and enzyme studies.

Authors:  J C Greenfield; N J Leonard; R I Gumport
Journal:  Biochemistry       Date:  1975-02-25       Impact factor: 3.162

10.  Substrate specificity of ribosomal peptidyltransferase. Effect of modification in the heterocyclic, carbohydrate and amino acid moiety of 2'(3')-O-L-phenylalanyladenosine.

Authors:  J Zemlicka; S Chládek; D Ringer; K Quiggle
Journal:  Biochemistry       Date:  1975-12-02       Impact factor: 3.162
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  1 in total

1.  Puromycin-rRNA interaction sites at the peptidyl transferase center.

Authors:  C Rodriguez-Fonseca; H Phan; K S Long; B T Porse; S V Kirillov; R Amils; R A Garrett
Journal:  RNA       Date:  2000-05       Impact factor: 4.942
  1 in total

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