Literature DB >> 7814089

Pharmacological effects of Azadirachta indica (neem) leaf extract on the ECG and blood pressure of rat.

K M Koley1, J Lal.   

Abstract

Neem leaf alcoholic extract (NLE) was investigated for its effects on the ECG and blood pressure of rat. Intravenous administration of NLE (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. NLE produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. Pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of NLE.

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Year:  1994        PMID： 7814089

Source DB:  PubMed          Journal:  Indian J Physiol Pharmacol        ISSN： 0019-5499


  4 in total

1.  Designing and screening of universal drug from neem (Azadirachta indica) and standard drug chemicals against influenza virus nucleoprotein.

Authors:  Aftab Ahmad; Muhammad Rizwan Javed; Abdul Qayyum Rao; Tayyab Husnain
Journal:  BMC Complement Altern Med       Date:  2016-12-16       Impact factor: 3.659

2.  Medicinal Plants in COVID-19: Potential and Limitations.

Authors:  Xin Yi Lim; Bee Ping Teh; Terence Yew Chin Tan
Journal:  Front Pharmacol       Date:  2021-03-24       Impact factor: 5.810

3.  Molecular docking based screening of neem-derived compounds with the NS1 protein of Influenza virus.

Authors:  Aftab Ahmad; Ammara Ahad; Abdul Qayyum Rao; Tayyab Husnain
Journal:  Bioinformation       Date:  2015-07-31

4.  Screening and design of anti-diabetic compounds sourced from the leaves of neem (Azadirachta indica).

Authors:  Asma Jalil; Usman Ali Ashfaq; Samar Shahzadi; Ijaz Rasul; Shahid-Ur Rehman; Masaud Shah; Muhammad Rizwan Javed; Muhammad Shareef Masoud
Journal:  Bioinformation       Date:  2013-12-27
  4 in total

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