Literature DB >> 7814019

Positional cloning of cDNAs from the human chromosome 3p21-22 region identifies a clustered organization of zinc-finger genes.

V Calabrò1, G Pengue, P C Bartoli, A Pagliuca, T Featherstone, L Lania.   

Abstract

The human 3p21-22 region is frequently involved in karyotype rearrangements associated with malignancies. The high frequency of allelic loss in this region has been associated with virtually all small cell lung carcinomas and many renal carcinomas. These findings suggest that at least one tumor-suppressor gene might be located in 3p21-22. We have recently reported the isolation of a 750-kb yeast artificial chromosome (YAC) contig from 3p21-22. Here, we describe three new genes isolated from the 3p YAC contig by using a cDNA hybridization selection. Remarkably, the three new genes encode zinc-finger proteins, indicating the presence of a cluster of zinc-finger genes in human chromosome 3p21.

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Year:  1995        PMID： 7814019     DOI： 10.1007/bf00225067

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  22 in total

1.  The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

Authors:  E J Bellefroid; D A Poncelet; P J Lecocq; O Revelant; J A Martial
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

2.  Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22.

Authors:  L Lanfrancone; G Pengue; P P Pandolfi; A E Salcini; A Giacomucci; L Longo; E Donti; P De Luca; G La Mantia; P G Pelicci
Journal:  Genomics       Date:  1992-04       Impact factor: 5.736

3.  An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor.

Authors:  D A Haber; A J Buckler; T Glaser; K M Call; J Pelletier; R L Sohn; E C Douglass; D E Housman
Journal:  Cell       Date:  1990-06-29       Impact factor: 41.582

4.  The human genome contains hundreds of genes coding for finger proteins of the Krüppel type.

Authors:  E J Bellefroid; P J Lecocq; A Benhida; D A Poncelet; A Belayew; J A Martial
Journal:  DNA       Date:  1989 Jul-Aug

5.  LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.

Authors:  J P Kerckaert; C Deweindt; H Tilly; S Quief; G Lecocq; C Bastard
Journal:  Nat Genet       Date:  1993-09       Impact factor: 38.330

6.  Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution.

Authors:  A Tunnacliffe; L Liu; J K Moore; M A Leversha; M S Jackson; L Papi; M A Ferguson-Smith; H J Thiesen; B A Ponder
Journal:  Nucleic Acids Res       Date:  1993-03-25       Impact factor: 16.971

7.  The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.

Authors:  H de Thé; C Lavau; A Marchio; C Chomienne; L Degos; A Dejean
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

8.  The ubiquitous transactivator Zfp-38 is upregulated during spermatogenesis with differential transcription.

Authors:  K Chowdhury; M Goulding; C Walther; K Imai; H Fickenscher
Journal:  Mech Dev       Date:  1992-12       Impact factor: 1.882

9.  A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias.

Authors:  M Djabali; L Selleri; P Parry; M Bower; B D Young; G A Evans
Journal:  Nat Genet       Date:  1992-10       Impact factor: 38.330

10.  Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

Authors:  Z Chen; N J Brand; A Chen; S J Chen; J H Tong; Z Y Wang; S Waxman; A Zelent
Journal:  EMBO J       Date:  1993-03       Impact factor: 11.598
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  3 in total

1.  Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.

Authors:  R Gonsky; J A Knauf; R Elisei; J W Wang; S Su; J A Fagin
Journal:  Nucleic Acids Res       Date:  1997-10-01       Impact factor: 16.971

2.  Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.

Authors:  M Centola; X Chen; R Sood; Z Deng; I Aksentijevich; T Blake; D O Ricke; X Chen; G Wood; N Zaks; N Richards; D Krizman; E Mansfield; S Apostolou; J Liu; N Shafran; A Vedula; M Hamon; A Cercek; T Kahan; D Gumucio; D F Callen; R I Richards; R K Moyzis; N A Doggett; F S Collins; P P Liu; N Fischel-Ghodsian; D L Kastner
Journal:  Genome Res       Date:  1998-11       Impact factor: 9.043

3.  miR-363-5p as potential prognostic marker for hepatocellular carcinoma indicated by weighted co-expression network analysis of miRNAs and mRNA.

Authors:  Jun Zhang; Jia Fan; Chongming Zhou; Yanyu Qi
Journal:  BMC Gastroenterol       Date:  2017-06-20       Impact factor: 3.067
  3 in total

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