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Literature DB >> 7813915

The human episome HALF1: structure of its genomic counterpart.

C Boccaccio¹, J Deschatrette, M Meunier-Rotival.

Abstract

A human episomal sequence (HALF1) has been identified by its ability to restore expression of hepatic functions when used to transfect a rat dedifferentiated cell line. The genomic equivalent of this human episome (gHALF1) and its flanking sequences were analyzed. HALF1 itself does not present the characteristics of a transposable element but half of its sequence corresponds to retroposons, including Alu and L1 repeats and a processed pseudogene, known to transpose via RNA intermediates. The structural characteristics of these different kinds of retroposons and their origin and evolution were analyzed.

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Year: 1994 PMID： 7813915 DOI： 10.1007/bf01435253

Source DB: PubMed Journal: Genetica ISSN： 0016-6707 Impact factor: 1.082

30 in total

1. Master genes in mammalian repetitive DNA amplification.

Authors: P L Deininger; M A Batzer; C A Hutchison; M H Edgell
Journal: Trends Genet Date: 1992-09 Impact factor: 11.639

2. Fusion of a free left Alu monomer and a free right Alu monomer at the origin of the Alu family in the primate genomes.

Authors: Y Quentin
Journal: Nucleic Acids Res Date: 1992-02-11 Impact factor: 16.971

Review 3. The origin and evolution of retroposons.

Authors: J H Rogers
Journal: Int Rev Cytol Date: 1985

4. L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein.

Authors: M Hattori; S Kuhara; O Takenaka; Y Sakaki
Journal: Nature Date: 1986 Jun 5-11 Impact factor: 49.962

The human episome HALF1: structure of its genomic counterpart.

1. Master genes in mammalian repetitive DNA amplification.

2. Fusion of a free left Alu monomer and a free right Alu monomer at the origin of the Alu family in the primate genomes.

Review 3. The origin and evolution of retroposons.

4. L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein.

5. Empty and occupied insertion site of the truncated LINE-1 repeat located in the mouse serum albumin-encoding gene.

6. Subfamily structure and evolution of the human L1 family of repetitive sequences.

7. A new subfamily of recently retroposed human Alu repeats.

8. Two-dimensional gel electrophoretic analysis of the HindIII 1.8-kb repetitive-sequence family in the human genome.

9. Unit-length line-1 transcripts in human teratocarcinoma cells.

10. Origin of the human L1 elements: proposed progenitor genes deduced from a consensus DNA sequence.

Review 1. Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity.