Literature DB >> 7813807

The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes.

D Owerbach1, K H Gabbay.   

Abstract

Type I diabetes susceptibility genes have been identified within the major histocompatibility complex (MHC) on chromosome 6p21.3 and near the VNTR/insulin region on chromosome 11p15.5. We have used polymorphic dinucleotide repeat markers to search the human genome for additional susceptibility genes in 162 type I diabetic families with an affected sibling pair. We report that an additional susceptibility gene is located on chromosome 2q31 near HOXD8 (P < 10(-5), maximum logarithm of odds score = 4.8) in an analysis of affected sibling pairs having specific human leukocyte antigen (HLA) and hypervariable nucleotide tandem repeat (VNTR)/insulin gene haplotypes (absence of high-risk HLA-DR3/4 haplotypes and presence of homozygous high-risk class I VNTR alleles). These results suggest the interaction of a minimum of three genes in the pathogenesis of type I diabetes in humans.

Entities:  

Mesh：

Year:  1995        PMID： 7813807     DOI： 10.2337/diab.44.1.132

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  14 in total

1.  In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.

Authors:  K A Metcalfe; G A Hitman; M J Fennessy; M I McCarthy; J Tuomilehto; E Tuomilehto-Wolf
Journal:  Diabetologia       Date:  1995-10       Impact factor: 10.122

Review 2.  From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.

Authors:  Alan G Baxter; Margaret A Jordan
Journal:  Rev Diabet Stud       Date:  2012-12-28

3.  The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families.

Authors:  J A Noble; A M Valdes; M Cook; W Klitz; G Thomson; H A Erlich
Journal:  Am J Hum Genet       Date:  1996-11       Impact factor: 11.025

4.  Association mapping of disease loci, by use of a pooled DNA genomic screen.

Authors:  L F Barcellos; W Klitz; L L Field; R Tobias; A M Bowcock; R Wilson; M P Nelson; J Nagatomi; G Thomson
Journal:  Am J Hum Genet       Date:  1997-09       Impact factor: 11.025

Review 5.  The genetics of complex ophthalmic disorders.

Authors:  K Evans; A C Bird
Journal:  Br J Ophthalmol       Date:  1996-08       Impact factor: 4.638

Review 6.  Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes.

Authors:  John P Driver; Yi-Guang Chen; Clayton E Mathews
Journal:  Rev Diabet Stud       Date:  2012-12-28

7.  A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions.

Authors:  J Nerup; F Pociot
Journal:  Am J Hum Genet       Date:  2001-10-11       Impact factor: 11.025

8.  Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.

Authors:  C J Fox; A D Paterson; S M Mortin-Toth; J S Danska
Journal:  Am J Hum Genet       Date:  2000-06-09       Impact factor: 11.025

9.  Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex.

Authors:  G Morahan; M Mehta; E McKinnon; I James
Journal:  Diabetes Obes Metab       Date:  2009-02       Impact factor: 6.577

10.  Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY).

Authors:  M Rewers; T L Bugawan; J M Norris; A Blair; B Beaty; M Hoffman; R S McDuffie; R F Hamman; G Klingensmith; G S Eisenbarth; H A Erlich
Journal:  Diabetologia       Date:  1996-07       Impact factor: 10.122
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