OBJECTIVE: To study the clinical risk factors for preterm premature rupture of membranes (PROM). METHOD: We conducted a case-control study of 138 patients with PROM between 24 and 35 weeks' gestation and 267 control subjects. RESULTS: In stepwise multiple logistic regression models, the population of cases was more likely to be of low social class. Other risk factors for PROM were smoking in pregnancy, 1st or 2nd-3rd trimester hemorrhages, cervical incompetence and a documented cervico-vaginal infection during index pregnancy. First trimester hemorrhage and a documented cervico-vaginal infection during index pregnancy were associated with preterm PROM both in nulliparous and in multiparous women. CONCLUSION: Few potentially remediable risk factors are associated with the occurrence of preterm PROM.
OBJECTIVE: To study the clinical risk factors for preterm premature rupture of membranes (PROM). METHOD: We conducted a case-control study of 138 patients with PROM between 24 and 35 weeks' gestation and 267 control subjects. RESULTS: In stepwise multiple logistic regression models, the population of cases was more likely to be of low social class. Other risk factors for PROM were smoking in pregnancy, 1st or 2nd-3rd trimester hemorrhages, cervical incompetence and a documented cervico-vaginal infection during index pregnancy. First trimester hemorrhage and a documented cervico-vaginal infection during index pregnancy were associated with preterm PROM both in nulliparous and in multiparous women. CONCLUSION: Few potentially remediable risk factors are associated with the occurrence of preterm PROM.
Authors: Jenna M Mennella; Lori A Underhill; Sophia Collis; Geralyn M Lambert-Messerlian; Richard Tucker; Beatrice E Lechner Journal: Reprod Sci Date: 2020-08-17 Impact factor: 3.060