Literature DB >> 7813554

Neurosteroids in the brain of handling-habituated and naive rats: effect of CO2 inhalation.

M L Barbaccia1, G Roscetti, M Trabucchi, T Cuccheddu, A Concas, G Biggio.   

Abstract

In rats habituated to the manipulation that precedes killing (handling-habituated) the cerebral cortical concentrations of pregnenolone and progesterone were significantly lower (-57% and -69%, respectively) than in naive animals. An acute stress, induced by CO2 inhalation, elicited a marked increase in the concentrations of pregnenolone, progesterone and deoxycorticosterone in the brain cortex and hippocampus of handling-habituated rats. An accepted stress, such as foot shock, also enhanced the brain cortical levels of pregnenolone, progesterone and deoxycorticosterone in handling-habituated rats. These data show that the rat brain cortical and hippocampal steroid content is related to the 'emotional state' of the animal.

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Year:  1994        PMID： 7813554     DOI： 10.1016/0014-2999(94)90123-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

Review 1.  Stress, ethanol, and neuroactive steroids.

Authors:  Giovanni Biggio; Alessandra Concas; Paolo Follesa; Enrico Sanna; Mariangela Serra
Journal:  Pharmacol Ther       Date:  2007-05-08       Impact factor: 12.310

2.  Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats.

Authors:  Cheryl A Frye; Madeline E Rhodes
Journal:  Neuroendocrinology       Date:  2006-10-04       Impact factor: 4.914

3.  2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats.

Authors:  M Serra; P Madau; M F Chessa; M Caddeo; E Sanna; G Trapani; M Franco; G Liso; R H Purdy; M L Barbaccia; G Biggio
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

Review 4.  The relevance of neuroactive steroids in schizophrenia, depression, and anxiety disorders.

Authors:  Erin M MacKenzie; John Odontiadis; Jean-Michel Le Mellédo; Trevor I Prior; Glen B I Baker
Journal:  Cell Mol Neurobiol       Date:  2007-08       Impact factor: 5.046

Review 5.  Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies.

Authors:  Patrizia Porcu; A Leslie Morrow
Journal:  Psychopharmacology (Berl)       Date:  2014-04-26       Impact factor: 4.530

6.  DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration.

Authors:  J M Torres; E Ortega
Journal:  Neurochem Res       Date:  2003-08       Impact factor: 3.996

7.  Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion.

Authors:  Phuong N Nguyen; Edwin B Yan; Margie Castillo-Melendez; David W Walker; Jonathan J Hirst
Journal:  J Physiol       Date:  2004-08-26       Impact factor: 5.182

8.  Functional correlation between allopregnanolone and [35S]-TBPS binding in the brain of rats exposed to isoniazid, pentylenetetrazol or stress.

Authors:  A Concas; M C Mostallino; C Perra; R Lener; G Roscetti; M L Barbaccia; R H Purdy; G Biggio
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

9.  Neurosteroid influences on sensitivity to ethanol.

Authors:  Christa M Helms; David J Rossi; Kathleen A Grant
Journal:  Front Endocrinol (Lausanne)       Date:  2012-01-31       Impact factor: 5.555

Review 10.  GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response.

Authors:  Benjamin G Gunn; Linda Cunningham; Scott G Mitchell; Jerome D Swinny; Jeremy J Lambert; Delia Belelli
Journal:  Front Neuroendocrinol       Date:  2014-06-12       Impact factor: 8.606
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