Literature DB >> 7812761

Swelling-induced K+ influx in cultured primary astrocytes.

A A Mongin1, S L Aksentsev, S N Orlov, N G Slepko, M V Kozlova, G V Maximov, S V Konev.   

Abstract

The effect of swelling of cultured primary astrocytes from rat brain in hypotonic medium on K+ influx has been studied. A decrease in osmolality from 310 to 180 mOsm increased the activity of sodium pump (ouabain-inhibited 86Rb+ influx) and Na+,K+,2Cl- cotransport (ouabain-insensitive bumetanide-inhibited 86Rb+ influx) by 70 and 35%, respectively. It is suggested that activation of these transport systems makes it possible to retain a high potassium concentration in the cells under regulatory volume decrease.

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Year:  1994        PMID： 7812761     DOI： 10.1016/0006-8993(94)91603-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

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