Literature DB >> 7812632

Close correlation of the cardioprotective effect of FK409, a spontaneous NO releaser, with an increase in plasma cyclic GMP level.

Y Kita1, T Sugimoto, Y Hirasawa, K Yoshida, K Maeda.   

Abstract

FK409 ((+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexeneamide) , which has been reported by us to be a new spontaneous nitric oxide (NO) releaser, prevented myocardial infarction following occlusion and reperfusion in rat coronary artery and increased plasma cyclic GMP level in rats, dose-dependently and significantly at 32 mg kg-1. Isosorbide dinitrate (ISDN), which is the most popular orally active NO donor used in the treatment of ischaemic cardiovascular diseases, did not show significant effects at 32 mg kg-1 in either experiment. Therefore, it is suggested that FK409 can attenuate myocardial injury during ischaemia and reperfusion in contrast to ISDN and a change in plasma cyclic GMP level may serve as an indicator of the cardioprotective effect of NO-releasing drugs.

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Year:  1994        PMID： 7812632      PMCID： PMC1510085          DOI： 10.1111/j.1476-5381.1994.tb16165.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Reduction of myocardial damage and polymorphonuclear leukocyte accumulation following coronary artery occlusion and reperfusion by the thromboxane receptor antagonist BM 13.505.

Authors:  E F Smith; D E Griswold; J W Egan; L M Hillegass; M J DiMartino
Journal:  J Cardiovasc Pharmacol       Date:  1989-05       Impact factor: 3.105

2.  Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409.

Authors:  Y Kita; Y Hirasawa; K Maeda; M Nishio; K Yoshida
Journal:  Eur J Pharmacol       Date:  1994-05-12       Impact factor: 4.432

3.  Neutrophil depletion suppresses 111In-labeled platelet accumulation in infarcted myocardium.

Authors:  M Bednar; B Smith; A Pinto; K M Mullane
Journal:  J Cardiovasc Pharmacol       Date:  1985 Sep-Oct       Impact factor: 3.105

4.  Beneficial effects of a new prostacyclin analogue, KP-10614, on acute myocardial infarction in rats.

Authors:  T Kanayama; Y Kimura; Y Tamao; S Mizogami
Journal:  J Cardiovasc Pharmacol       Date:  1992-10       Impact factor: 3.105

5.  Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase.

Authors:  M Feelisch; E A Noack
Journal:  Eur J Pharmacol       Date:  1987-07-02       Impact factor: 4.432

6.  Kinetics and imaging of indium-11-labeled autologous platelets in experimental myocardial infarction.

Authors:  K H Laws; J A Clanton; V A Starnes; F M Lupinetti; J C Collins; J A Oates; J W Hammon
Journal:  Circulation       Date:  1983-01       Impact factor: 29.690

7.  Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia.

Authors:  G L Stahl; Z Terashita; A M Lefer
Journal:  J Pharmacol Exp Ther       Date:  1988-03       Impact factor: 4.030

8.  Plasma cyclic guanosine monophosphate in chronic heart failure: hemodynamic and neurohormonal correlations and response to nitrate therapy.

Authors:  A Shotan; A Mehra; E Ostrzega; W Hsueh; Y S Do; D A Fisher; A Hurst; J V Johnson; U Elkayam
Journal:  Clin Pharmacol Ther       Date:  1993-12       Impact factor: 6.875

9.  Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron.

Authors:  M Feelisch; E Noack
Journal:  Eur J Pharmacol       Date:  1987-10-27       Impact factor: 4.432
  9 in total
  4 in total

Review 1.  Biochemistry of the infarcted heart.

Authors:  R J Bing; A M Cohen
Journal:  Neurochem Res       Date:  1999-09       Impact factor: 3.996

2.  Nitric oxide (NO)-releasing pathway of FK409 in the presence of sulfhydryl-bearing compounds.

Authors:  S Fukuyama; T Azuma; Y Hirasawa; N Morokoshi; T Akama; S Koda; Y Kita
Journal:  Pharm Res       Date:  1996-08       Impact factor: 4.200

3.  Failure of nitric oxide donors to alter arrhythmias induced by acute myocardial ischaemia or reperfusion in anaesthetized rats.

Authors:  C S Barnes; S J Coker
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

4.  Antianginal effects of FK409, a new spontaneous NO releaser.

Authors:  Y Kita; R Ozaki; S Sakai; T Sugimoto; Y Hirasawa; M Ohtsuka; H Senoh; K Yoshida; K Maeda
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739
  4 in total

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