Literature DB >> 781181

Porphobilinogen-accumulating mutants of Salmonella typhimurium LT2.

A Săsărman, M Desrochers, S Sonea, K E Sanderson, M Surdeanu.   

Abstract

Four independent porphobilinogen-accumulating mutants of Salmonella typhimurium LT2 were isolated by selecting for dwarf colony formation on neomycin agar media. Cell-free extracts of the parent strain, but not of the mutants, were able to convert 5-aminolaevulinic acid or porphobilinogen to porphyrins. The results indicated that the mutants were deficient in uroporphyrinogen I synthase (EC. 4.3.I. 8) activity: these are the first mutants of this type reported in S. typhimurium LT2. Mapping of the hemC locus (for uroporphyrinogen I synthase) by F-mediated conjugation and by P22-mediated transduction showed the gene sequence ilvEDAC-hemC-cya-metE.

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Year:  1976        PMID： 781181     DOI： 10.1099/00221287-94-2-359

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  9 in total

Review 1.  Linkage map of Salmonella typhimurium, edition V.

Authors:  K E Sanderson; P E Hartman
Journal:  Microbiol Rev       Date:  1978-06

2.  Porphobilinogen-accumulation by a porphyrin auxotrophic strain of Bacillus subtilis.

Authors:  A Miczák; A Juhász
Journal:  Experientia       Date:  1978-09-15

3.  Uroporphyrinogen III cosynthase-deficient mutant of Salmonella typhimurium LT2.

Authors:  A Săsárman; M Desrochers
Journal:  J Bacteriol       Date:  1976-12       Impact factor: 3.490

Review 4.  Linkage map of Salmonella typhimurium, Edition VI.

Authors:  K E Sanderson; J R Roth
Journal:  Microbiol Rev       Date:  1983-09

5.  Molecular cloning and sequencing of the hemD gene of Escherichia coli K-12 and preliminary data on the Uro operon.

Authors:  A Sasarman; A Nepveu; Y Echelard; J Dymetryszyn; M Drolet; C Goyer
Journal:  J Bacteriol       Date:  1987-09       Impact factor: 3.490

6.  Heme-deficient mutants of Salmonella typhimurium: two genes required for ALA synthesis.

Authors:  T Elliott; J R Roth
Journal:  Mol Gen Genet       Date:  1989-04

7.  Mapping of the hemE locus in Salmonella typhimurium.

Authors:  M Desrochers; L Peloquin; A Săsărman
Journal:  J Bacteriol       Date:  1978-09       Impact factor: 3.490

8.  The genes required for heme synthesis in Salmonella typhimurium include those encoding alternative functions for aerobic and anaerobic coproporphyrinogen oxidation.

Authors:  K Xu; J Delling; T Elliott
Journal:  J Bacteriol       Date:  1992-06       Impact factor: 3.490

9.  Coproporphyrin excretion and low thiol levels caused by point mutation in the Rhodobacter sphaeroides S-adenosylmethionine synthetase gene.

Authors:  Monique Sabaty; Géraldine Adryanczyk; Chloë Roustan; Stephan Cuiné; Christine Lamouroux; David Pignol
Journal:  J Bacteriol       Date:  2009-12-28       Impact factor: 3.490
  9 in total

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