Literature DB >> 7811565

Accumulation of L-[2-(F-18)]fluorophenylalanine in peri-infarct area in a patient with acute cerebral infarction.

J Hatazawa1, H Itoh, E Shimosegawa, I Kanno, M Murakami, S Miura, H Iida, T Okudera, A Inugami, T Ogawa.   

Abstract

We studied the brain uptake of amino acid in a patient with acute cerebral infarction with L-[2-(F-18)]fluorophenylalanine and positron emission tomography. The increased accumulation of the ligand was specifically found in the peri-infarct area where oxygen metabolism was still maintained but decreased later in the 72-day follow-up period. The kinetic analysis revealed that increased accumulation was not due to increased transport from the blood to the brain but delayed washout from the brain to the blood. Although the mechanism is still unknown, abnormally high accumulation of L-[F-18]fluorophenylalanine may predict delayed neuronal changes after ischemic insults of the brain.

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Year:  1994        PMID： 7811565     DOI： 10.1007/bf03165000

Source DB:  PubMed          Journal:  Ann Nucl Med        ISSN： 0914-7187            Impact factor:   2.668


  11 in total

1.  Progressive derangement of periinfarct viable tissue in ischemic stroke.

Authors:  W D Heiss; M Huber; G R Fink; K Herholz; U Pietrzyk; R Wagner; K Wienhard
Journal:  J Cereb Blood Flow Metab       Date:  1992-03       Impact factor: 6.200

2.  Recovery of monkey brain after prolonged ischemia. II. Protein synthesis and morphological alterations.

Authors:  W Bodsch; A Barbier; M Oehmichen; B Grosse Ophoff; K A Hossmann
Journal:  J Cereb Blood Flow Metab       Date:  1986-02       Impact factor: 6.200

3.  Use of [11C]aminocyclohexanecarboxylate for the measurement of amino acid uptake and distribution volume in human brain.

Authors:  R A Koeppe; T Mangner; A L Betz; B L Shulkin; R Allen; P Kollros; D E Kuhl; B W Agranoff
Journal:  J Cereb Blood Flow Metab       Date:  1990-09       Impact factor: 6.200

Review 4.  Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis.

Authors:  B K Siesjö; F Bengtsson
Journal:  J Cereb Blood Flow Metab       Date:  1989-04       Impact factor: 6.200

5.  [Clinical investigation of 18F-fluorophenylalanine for brain tumor imaging--comparison with 11C-methionine].

Authors:  F Shishido; M Murakami; S Miura; K Takahashi; A Inugami; N Tomura; S Higano; H Fujita; I Kanno; H Sasaki
Journal:  Kaku Igaku       Date:  1988-12

6.  Regional protein synthesis in rat brain following acute hemispheric ischemia.

Authors:  G A Dienel; W A Pulsinelli; T E Duffy
Journal:  J Neurochem       Date:  1980-11       Impact factor: 5.372

7.  Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography.

Authors:  M A Mintun; M E Raichle; W R Martin; P Herscovitch
Journal:  J Nucl Med       Date:  1984-02       Impact factor: 10.057

8.  Evaluation of critically perfused area in acute ischemic stroke for therapeutic reperfusion: a clinical PET study.

Authors:  S Higano; K Uemura; F Shishido; I Kanno; N Tomura; K Sakamoto
Journal:  Ann Nucl Med       Date:  1993-08       Impact factor: 2.668

9.  L-[2-18F]fluorophenylalanine and L-[U-14C]phenylalanine: a comparative study of their transport to rat brain.

Authors:  H Nakamichi; M Murakami; S Miura; Y Kondoh; S Mizusawa; Y Ono
Journal:  Nucl Med Biol       Date:  1993-01       Impact factor: 2.408

10.  Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans.

Authors:  W J Powers; R L Grubb; D Darriet; M E Raichle
Journal:  J Cereb Blood Flow Metab       Date:  1985-12       Impact factor: 6.200
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  2 in total

1.  Quantitative evaluation of neutral amino acid transport in cerebral gliomas using positron emission tomography and fluorine-18 fluorophenylalanine.

Authors:  T Ogawa; S Miura; M Murakami; H Iida; J Hatazawa; A Inugami; I Kanno; N Yasui; T Sasajima; K Uemura
Journal:  Eur J Nucl Med       Date:  1996-08

2.  Proliferation-dependent changes in amino acid transport and glucose metabolism in glioma cell lines.

Authors:  Toshio Sasajima; Tadashi Miyagawa; Takamitsu Oku; Juri G Gelovani; Ronald Finn; Ronald Blasberg
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-05-13       Impact factor: 9.236
  2 in total

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