Literature DB >> 7811054

Penetration of cefotetan into suction skin blister fluid and tissue homogenates in patients undergoing abdominal surgery.

T Mazzei1, F Tonelli, A Novelli, F Ficari, C Mazzoni, A Anastasi, P Periti.   

Abstract

The penetration of cefotetan (2-g intravenous bolus) into the suction blister fluid and tissue homogenates of 11 patients was investigated. Mean concentrations in tissue were significantly lower than contemporary suction blister fluid levels. These data show that the determination of beta-lactam concentrations by the tissue homogenate method may seriously underestimate the actual antibiotic levels in extracellular fluid.

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Year:  1994        PMID： 7811054      PMCID： PMC284719          DOI： 10.1128/AAC.38.9.2221

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

Review 1.  Pulmonary disposition of antimicrobial agents: in vivo observations and clinical relevance.

Authors:  D R Baldwin; D Honeybourne; R Wise
Journal:  Antimicrob Agents Chemother       Date:  1992-06       Impact factor: 5.191

Review 2.  Pharmacokinetics of antibiotics in tissues and tissue fluids: a review.

Authors:  O Cars
Journal:  Scand J Infect Dis Suppl       Date:  1990

Review 3.  Antibiotic tissue penetration and its relevance: models of tissue penetration and their meaning.

Authors:  D E Nix; S D Goodwin; C A Peloquin; D L Rotella; J J Schentag
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

Review 4.  Antibiotic tissue penetration and its relevance: impact of tissue penetration on infection response.

Authors:  D E Nix; S D Goodwin; C A Peloquin; D L Rotella; J J Schentag
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

5.  Tissue distribution of cefotetan in patients with Crohn's disease.

Authors:  T Mazzei; F Tonelli; A Anastasi; F Ficari; A Novelli; P Periti
Journal:  Chemotherapy       Date:  1991       Impact factor: 2.544

Review 6.  The clinical relevance of protein binding and tissue concentrations in antimicrobial therapy.

Authors:  R Wise
Journal:  Clin Pharmacokinet       Date:  1986 Nov-Dec       Impact factor: 6.447

7.  Effect of the ratio of surface area to volume on the penetration of antibiotics in to extravascular spaces in an in vitro model.

Authors:  L L Van Etta; L R Peterson; C E Fasching; D N Gerding
Journal:  J Infect Dis       Date:  1982-09       Impact factor: 5.226

Review 8.  Antibiotic assays in muscle: are conventional tissue levels misleading as indicator of the antibacterial activity?

Authors:  D M Ryan; O Cars
Journal:  Scand J Infect Dis       Date:  1980

9.  Pharmacokinetics of single intravenous and intramuscular doses of cefotetan in normal human volunteers.

Authors:  J Guibert; M D Kitzis; C Yvelin; J F Acar
Journal:  J Antimicrob Chemother       Date:  1983-01       Impact factor: 5.790

10.  A problem in the interpretation of beta-lactam antibiotic levels in tissues.

Authors:  D M Ryan; O Cars
Journal:  J Antimicrob Chemother       Date:  1983-09       Impact factor: 5.790
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  3 in total

Review 1.  Drug monitoring in nonconventional biological fluids and matrices.

Authors:  S Pichini; I Altieri; P Zuccaro; R Pacifici
Journal:  Clin Pharmacokinet       Date:  1996-03       Impact factor: 6.447

2.  Pharmacokinetic evaluation of meropenem and imipenem in critically ill patients with sepsis.

Authors:  Andrea Novelli; Chiara Adembri; Paola Livi; Stefania Fallani; Teresita Mazzei; Angelo Raffaele De Gaudio
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

3.  Antibiotic pharmacodynamics in surgical prophylaxis: an association between intraoperative antibiotic concentrations and efficacy.

Authors:  Sheryl A Zelenitsky; Robert E Ariano; Godfrey K M Harding; Richard E Silverman
Journal:  Antimicrob Agents Chemother       Date:  2002-09       Impact factor: 5.191
  3 in total

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