Literature DB >> 7807127

Hamacanthins A and B, new antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp.

S P Gunasekera1, P J McCarthy, M Kelly-Borges.   

Abstract

Hamacanthin A [1] and hamacanthin B [2] are two bioactive dihydropyrazinonediylbis(indole) alkaloids isolated from a new species of deep-water marine sponge, Hamacantha sp. The hamacanthins are growth inhibitors of Candida albicans and Cryptococcus neoformans. Isolation and structure elucidation of 1 and 2 by nmr spectroscopy are described.

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Year:  1994        PMID： 7807127     DOI： 10.1021/np50112a014

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

1.  Synthesis of 4-aryl-6-indolylpyridine-3-carbonitriles and evaluation of their antiproliferative activity.

Authors:  Naglaa Salem El-Sayed; Amir Nasrolahi Shirazi; Magda Goda El-Meligy; Ahmed Kamel El-Ziaty; Zenat Adeeb Nagib; Keykavous Parang
Journal:  Tetrahedron Lett       Date:  2014-02-05       Impact factor: 2.415

2.  Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities.

Authors:  Mukund P Tantak; Vishakha Gupta; Kumar Nikhil; V Arun; Rajnish Prakash Singh; Prabhat Nath Jha; Kavita Shah; Dalip Kumar
Journal:  Bioorg Med Chem Lett       Date:  2016-04-28       Impact factor: 2.823

Review 3.  The Mechanistic Targets of Antifungal Agents: An Overview.

Authors:  Tryphon K Mazu; Barbara A Bricker; Hernan Flores-Rozas; Seth Y Ablordeppey
Journal:  Mini Rev Med Chem       Date:  2016       Impact factor: 3.862

4.  Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.

Authors:  Sandip B Bharate; Jaideep B Bharate; Shabana I Khan; Babu L Tekwani; Melissa R Jacob; Ramesh Mudududdla; Rammohan R Yadav; Baljinder Singh; P R Sharma; Sudip Maity; Baldev Singh; Ikhlas A Khan; Ram A Vishwakarma
Journal:  Eur J Med Chem       Date:  2013-02-28       Impact factor: 6.514

5.  6"-Debromohamacanthin A, a bis (indole) alkaloid, inhibits angiogenesis by targeting the VEGFR2-mediated PI3K/AKT/mTOR signaling pathways.

Authors:  Gi Dae Kim; Oug Jae Cheong; Song Yi Bae; Jongheon Shin; Sang Kook Lee
Journal:  Mar Drugs       Date:  2013-04-02       Impact factor: 5.118

6.  Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites.

Authors:  Amy E Wright; K Brian Killday; Debopam Chakrabarti; Esther A Guzmán; Dedra Harmody; Peter J McCarthy; Tara Pitts; Shirley A Pomponi; John K Reed; Bracken F Roberts; Carolina Rodrigues Felix; Kyle H Rohde
Journal:  Mar Drugs       Date:  2017-01-11       Impact factor: 5.118

7.  Rhodium-catalyzed C-H functionalization of heteroarenes using indoleBX hypervalent iodine reagents.

Authors:  Erwann Grenet; Ashis Das; Paola Caramenti; Jérôme Waser
Journal:  Beilstein J Org Chem       Date:  2018-05-25       Impact factor: 2.883

8.  Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives.

Authors:  Muhammad Taha; Imad Uddin; Mohammed Gollapalli; Noor Barak Almandil; Fazal Rahim; Rai Khalid Farooq; Muhammad Nawaz; Mohamed Ibrahim; Mohammed A Alqahtani; Yasser A Bamarouf; Manikandan Selvaraj
Journal:  BMC Chem       Date:  2019-08-06

9.  The Hexameric Resorcinarene Capsule as a Brønsted Acid Catalyst for the Synthesis of Bis(heteroaryl)methanes in a Nanoconfined Space.

Authors:  Stefania Gambaro; Pellegrino La Manna; Margherita De Rosa; Annunziata Soriente; Carmen Talotta; Carmine Gaeta; Placido Neri
Journal:  Front Chem       Date:  2019-10-22       Impact factor: 5.221

10.  A general synthesis of bis-indolylpiperazine-2,5-diones.

Authors:  Stephen Crooke; Christine Whitlock
Journal:  Molecules       Date:  2012-12-13       Impact factor: 4.411
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