Literature DB >> 7806912

Colonic proteolysis following pancreatic duct ligation in the rat.

D Bustos1, O Tiscornia, M I Caldarini, G Negri, S Pons, K Ogawa, J A De Paula.   

Abstract

Luminal proteolytic activity (PA) of different colonic segments was ascertained in animals subjected to pancreatic duct ligation (PDL) and in control rats. The PDL rats revealed a significant PA reduction in the cecum, proximal colon (P < 0.01), and distal colon (P < 0.005). Proteolytic activity, trypsin, and chymotrypsin activity in control rats diminished progressively from the cecum to the distal colon. Conversely in PDL rats, we found maximal PA in distal colon. The conclusion is drawn that a significant proportion of colonic proteolytic activity can be attributed to pancreatic proteases with a maximal contribution at cecum level.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7806912     DOI： 10.1007/bf02925609

Source DB:  PubMed          Journal:  Int J Pancreatol        ISSN： 0169-4197


  16 in total

1.  Role of pancreatic proteases in the pathogenesis of ischemic enteropathy.

Authors:  G Bounous; D Menard; E De Medicis
Journal:  Gastroenterology       Date:  1977-07       Impact factor: 22.682

2.  PROTEIN PRODUCING CAPACITY OF THE HUMAN EXOCRINE PANCREAS: INCORPORATION OF S35 METHIONINE IN SERUM AND PANCREATIC JUICE PROTEIN.

Authors:  J C KUKRAL; A P ADAMS; F W PRESTON
Journal:  Ann Surg       Date:  1965-07       Impact factor: 12.969

3.  The absorption of glycine and alanine and their peptides by Lactobacillus casei.

Authors:  F R LEACH; E E SNELL
Journal:  J Biol Chem       Date:  1960-12       Impact factor: 5.157

4.  Fermentation of Peptides by Bacteroides ruminicola B(1)4.

Authors:  J B Russell
Journal:  Appl Environ Microbiol       Date:  1983-05       Impact factor: 4.792

5.  Protein degradation by human intestinal bacteria.

Authors:  G T Macfarlane; J H Cummings; C Allison
Journal:  J Gen Microbiol       Date:  1986-06

6.  A sensitive new substrate for chymotrypsin.

Authors:  E G DelMar; C Largman; J W Brodrick; M C Geokas
Journal:  Anal Biochem       Date:  1979-11-01       Impact factor: 3.365

7.  Quantitation of active pancreatic endopeptidases in the intestinal contents of germfree and conventional rats.

Authors:  S Genell; B E Gustafsson; K Ohlsson
Journal:  Scand J Gastroenterol       Date:  1976       Impact factor: 2.423

8.  Determination of immunoreactive trypsin, pancreatic elastase and chymotrypsin in extracts of human feces and ileostomy drainage.

Authors:  M Bohe; A Borgström; S Genell; K Ohlsson
Journal:  Digestion       Date:  1983       Impact factor: 3.216

9.  Contribution of the microflora to proteolysis in the human large intestine.

Authors:  G T Macfarlane; C Allison; S A Gibson; J H Cummings
Journal:  J Appl Bacteriol       Date:  1988-01

10.  Influence of retention time on degradation of pancreatic enzymes by human colonic bacteria grown in a 3-stage continuous culture system.

Authors:  G T Macfarlane; J H Cummings; S Macfarlane; G R Gibson
Journal:  J Appl Bacteriol       Date:  1989-11
View more
  3 in total

1.  Luminal trypsin induces enteric nerve-mediated anion secretion in the mouse cecum.

Authors:  Osamu Ikehara; Hisayoshi Hayashi; Toshiharu Waguri; Izumi Kaji; Shin-ichiro Karaki; Atsukazu Kuwahara; Yuichi Suzuki
Journal:  J Physiol Sci       Date:  2014-01-14       Impact factor: 2.781

2.  Protein hydrolysates stimulate proglucagon gene transcription in intestinal endocrine cells via two elements related to cyclic AMP response element.

Authors:  J-C Gevrey; M Malapel; J Philippe; G Mithieux; J-A Chayvialle; J Abello; M Cordier-Bussat
Journal:  Diabetologia       Date:  2004-04-14       Impact factor: 10.122

3.  Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2.

Authors:  D Darmoul; J C Marie; H Devaud; V Gratio; M Laburthe
Journal:  Br J Cancer       Date:  2001-09-01       Impact factor: 7.640
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.